Promotes Laryngeal Carcinoma Proliferation and Migration Through Pathway by .

Background: Laryngeal cancer (LC) remains one of the most common tumors of the respiratory tract, the exact pathogenesis remains unclear. is aberrantly expressed in a variety of cancers and plays a pro- or anti-cancer role, but is indistinct in LC.

Objectives: Showing the role of in the development of LC.

Materials And Methods: Quantitative reverse transcription-polymerase chain reaction was used for measurement in clinical samples and LC cell lines (AMC-HN8 and TU212), first. The expression of was inhibited by inhibitor, then followed clonogenic and flow cytometric assays for cell proliferation; wood healing, and Transwell assays for cell migration. Dual luciferase reporter assay was performed for interaction verification, and the activation of the signal pathway was detected by western blots.

Results: was significantly over-expressed in LC tissues and cell lines. The proliferation ability of the LC cells was significantly reduced after inhibition, and most LC cells were stagnated in the G1 phase. The migration and invasion ability of the LC cells was decreased after the knockdown. Further, we found that is bound with 3'-UTR of AKT interacting protein () mRNA specifically, and then activate pathway in LC cells.

Conclusions: A new mechanism was uncovered that miR-106a-5p promotes LC development via axis, which guides clinical management and drug discovery.