Background: All life strives to be well, but not all life is well. This suggests that cognition aimed at improving and protecting well-being might share a common core across all life forms: core cognition.
Objective: In this first of a two-part theoretical article, we systematically specify the evolutionary core cognition of well-being from the perspective of general living agents. In Part 2 we apply this to identity development and the theoretical approaches to well-being. This first part aims to identify the strategies and conditions for the creation and protection of generalized well-being and describes associated behavioral ontologies.
Results: We defined a set of key terms that, together, specify core cognition. This set comprises quite naturally concepts like agency, behavior, need satisfaction, intelligence, authority, power, and wisdom, which are all derived from the defining properties of life. We derived coping and co-creation as two essentially different, but complementary, behavioral ontologies. Copingis for survival and targeted problem solving and aims to end the need for its activation. Co-creation is for thriving and problem prevention and aims to perpetuate its activation. Co-creation can explain the growth of the biosphere. While both strategies are essential, the successful interplay of their strengths leads to the dominance of one of them: co-creation. Absence of success leads to a dominance of coping: a coping-trap and a strong urge to curtail behavioral diversity. We summarize the key terms of core cognition and the ontologies in two tables with defined terms.
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http://dx.doi.org/10.11621/pir2021.0110 | DOI Listing |
The apolipoprotein E ( ) ε4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites, yet the impact and function of this glycosylation on AD biomarkers remains unclear. We examined apoE glycosylation in a cohort of cerebrospinal fluid (CSF, n=181) and plasma (n= 178) samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) stratified into 4 groups: cognitively normal (CN), Mild Cognitive Impairment (MCI), progressors and non-progressors based on delayed word recall performance over 4 years.
View Article and Find Full Text PDFThe ability to observe the social behavior of others and use observed information to bias future action is a fundamental building block of social cognition . A foundational question is whether social observation and experience engage common circuit mechanisms that enable behavioral change. While classic studies on social learning have shown that aggressive behaviors can be learned through observation , it remains unclear whether aggression observation promotes persistent neural changes that generalize to new contexts.
View Article and Find Full Text PDFObjective: The 2024 Alzheimer's Association (AA) research diagnostic criteria for Alzheimer's Disease (AD) considers fluid biomarkers, including promising blood-based biomarkers for detecting AD. This study aims to identify dementia subtypes and their cognitive and neuroimaging profiles in older adults with dementia in the Democratic Republic of Congo (DRC) using biomarkers and clinical data.
Methods: Forty-five individuals with dementia over 65 years old were evaluated using the Community Screening Instrument for Dementia and the informant-based Alzheimer's Questionnaire.
Autism Res
January 2025
Department of Physical Therapy, University of Delaware, Newark, Delaware, USA.
Children with autism spectrum disorder (ASD) display a variety of core and co-occurring difficulties in social, communication, everyday functioning, cognitive, motor, and language domains. Receiving a combination of services to accommodate needs of autistic individuals is essential for improving their future outcomes. During the COVID-19 pandemic, reduced service access negatively impacted autistic children's outcomes.
View Article and Find Full Text PDFCell Commun Signal
January 2025
Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the development of cognitive dysfunction in individuals with T2DM remain elusive. Herein, we discussed the role of Bmal1, a core circadian rhythm-regulating gene, in the process of T2DM-associated cognitive dysfunction.
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