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Full kinetic modeling analysis of [F]fluorocholine Positron Emission Tomography (PET) at initial diagnosis of high-grade glioma.
Neuroimage Clin
June 2024
Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain.
Purpose: The main objective was to characterize the tracer uptake kinetics of [F]fluoromethylcholine ([F]F-CHO) in high-grade gliomas (HGG) through a full PET kinetic modeling approach. Secondarily, we aimed to explore the relationship between the PET uptake measures and the HGG molecular features.
Materials And Methods: Twenty-four patients with a suspected diagnosis of HGG were prospectively included.
Preoperative identification of small parathyroid adenomas-better done by fluorocholine positron emission tomography/computed tomography.
Gland Surg
December 2023
Department of General and Visceral Surgery, Cantonal Hospital of Aarau, Aarau, Switzerland.
Background: Preoperative localization imaging studies are crucial for safe and successful parathyroidectomy in patients with primary hyperparathyroidism (pHPT), especially in focused approaches. A common imaging sequence is ultrasound followed by scintigraphy. These techniques, but not 18F-fluorocholine positron emission tomography/computed tomography (PET/CT), show lower detection rates in multiglandular disease (MGD), which is associated with smaller adenomas.
View Article and Find Full Text PDFArticle Synopsis
- The study compared the effectiveness of 18F-PSMA-1007 (PSMA) and 18F-Choline PET/CT (FCH) in detecting prostate cancer recurrence in 186 patients who had previously received treatment.
- Findings revealed that PSMA had a significantly higher detection rate (84%) compared to FCH (69%), along with greater sensitivity, making it the more reliable option for diagnosing biochemically recurrent prostate cancer.
- The research concluded that PSMA is superior to FCH in identifying metastatic lesions, especially at lower PSA levels, enhancing diagnostic accuracy in prostate cancer patients experiencing recurrence.
Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism.
Osteoporos Int
January 2024
Université de Paris-APHP.Centre, Service de Rhumatologie, Hôpital Cochin, Centre de Référence des Maladies Rares du Métabolisme Phospho-calcique, Paris, France.
Bone lytic lesions are a possible complication of pseudohypoparathyroidism type 1B, in undertreated adult patients. Whole body [18F] F-fluorocholine PET/CT is a useful imaging tool to assess brown tumor progression in this context. We describe the case of a 33-year-old woman, referred for the diagnostic evaluation of lytic bone lesions of the lower limbs, in the context of asymptomatic pseudohypoparathyroidism.
View Article and Find Full Text PDFCorrection to: [F]Fluorocholine Uptake of Parathyroid Adenoma is Correlated with Parathyroid Hormone Level.
Mol Imaging Biol
June 2023
Department of Nuclear Medicine, University Hospital Zurich / University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
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