AI Article Synopsis
- Post-operative nausea and vomiting (PONV) is a frequent issue after sleeve gastrectomy, prompting the development of prevention strategies like enhanced recovery after surgery (ERAS) and various antiemetics.
- In a study with 130 patients, those receiving a combination of metoclopramide and ondansetron (MO group) had a lower incidence of PONV (46.1%) compared to the control group (53.8%) and others, with no need for rescue antiemetics.
- The study concludes that combining metoclopramide and ondansetron is an effective antiemetic approach for reducing PONV after sleeve gastrectomy, especially when used with ERAS
Article Abstract
Introduction: Post-operative nausea and vomiting (PONV) is a common problem after sleeve gastrectomy. In recent years, following the increase in the number of such operations, special attention has been paid to preventing PONV. Additionally, several prophylaxis methods have been developed, including enhanced recovery after surgery (ERAS) and preventive antiemetics. Nevertheless, PONV has not been completely eliminated, and the clinicians are trying to reduce the incidence of PONV yet.
Methods: After successful ERAS implementation, patients were divided into five groups, including control and experimental groups. Metoclopramide (MA), ondansetron (OA), granisetron (GA), and a combination of metoclopramide and ondansetron (MO) were used as antiemetics for each group. The frequency of PONV during the first and second days of admission was recorded using a subjective PONV scale.
Results: A total of 130 patients were enrolled in this study. The MO group showed a lower incidence of PONV (46.1%) compared to the control group (53.8%) and other groups. Furthermore, the MO group did not require rescue antiemetics, however, one-third of control cases used rescue antiemetics (0 vs. 34%).
Conclusion: Using the combination of metoclopramide and ondansetron is recommended as the antiemetic regimen for the reduction of PONV after sleeve gastrectomy. This combination is more helpful when implemented alongside ERAS protocols.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942645 | PMC |
| http://dx.doi.org/10.1007/s00464-023-09939-2 | DOI Listing |
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