AI Article Synopsis

  • - The study investigates the relationship between peripheral blood biomarkers (PBBMs) and outcomes in patients with recurrent/metastatic head and neck squamous cell carcinomas (R/M HNSCC) treated with immune checkpoint inhibitors (ICIs) from 2012 to 2021.
  • - It analyzed data from 186 patients and found that higher levels of lactate dehydrogenase (LDH) and absolute neutrophil counts, along with lower lymphocyte percentages, were associated with poorer overall survival and response to treatment.
  • - The findings suggest that these PBBMs could help predict patient outcomes and should be further studied in future research to validate their potential as biomarkers in immunotherapy treatment.

Article Abstract

Background: Little is known regarding associations between peripheral blood biomarkers (PBBMs) and survival, response, and toxicity in recurrent/metastatic head and neck squamous cell carcinomas (R/M HNSCC) treated with immune checkpoint inhibitors (ICIs).

Methods: In this single-institution retrospective cohort study, a dataset of patients with R/M HNSCC treated with ICIs between 08/2012-03/2021 was established, including demographic and clinicopathologic characteristics. Pretreatment PBBMs were collected and evaluated for associations with grade ≥3 adverse events (G ≥ 3AE) by CTCAEv5, objective response (ORR) by RECIST 1.1, overall survival (OS), and progression-free survival (PFS). Multivariable models for each outcome were created using elastic net variable selection.

Results: Our study included 186 patients, with 51 (27%) demonstrating complete or partial response to immunotherapy. Multivariable models adjusted for ECOG performance status (PS), p16, and smoking demonstrated that pretreatment higher LDH and absolute neutrophils, as well as lower percent lymphocytes correlated with worse OS and PFS. Higher LDH and lower % lymphocytes also correlated with worse ORR.

Conclusions: In the largest study to date examining PBBMs in ICI-treated R/M HNSCCs, our variable selection method revealed PBBMs prognostic for survival and response to immunotherapy. These biomarkers warrant further investigation in a prospective study along with validation with CPS biomarker.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166901PMC
http://dx.doi.org/10.1002/cam4.5697DOI Listing

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