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Reinvigorating the JLB experience.
J Leukoc Biol
March 2023
Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Breakthrough concepts in immune-oncology: Cancer vaccines at the bedside.
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October 2020
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Clinical approval of the immune checkpoint blockade (ICB) agents for multiple cancer types has reinvigorated the long-standing work on cancer vaccines. In the pre-ICB era, clinical efforts focused on the Ag, the adjuvants, the formulation, and the mode of delivery. These translational efforts on therapeutic vaccines range from cell-based (e.
View Article and Find Full Text PDFUnravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis.
J Leukoc Biol
June 2020
Department of Inflammation and Oncology, Amgen Research, Amgen Inc., South San Francisco, California, USA.
T cells are crucial for the success of immune-based cancer therapy. Reinvigorating antitumor T cell activity by blocking checkpoint inhibitory receptors has provided clinical benefits for many cancer patients. However, the efficacy of these treatments varies in cancer patients and the mechanisms underlying these diverse responses remain elusive.
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