Promoting photothermal antibacterial activity through an excited-state intramolecular proton transfer process.

J Mater Chem B

Hubei Key Lab on Organic and Polymeric Opto-Electronic Materials, TaiKang Center for Life and Medical Sciences, Sauvage Center for Molecular Sciences, Department of Chemistry, Wuhan University, Wuhan, 430072, China.

Published: June 2023

AI Article Synopsis

  • Scientists are developing a new way to fight infections caused by bacteria that don’t respond to regular medicine.
  • They created a special material that gets really hot (up to 55 °C) in just 10 seconds when exposed to light, making it effective against these tough bacteria.
  • This new method can help heal infected wounds much faster than older treatments, and it could lead to better bandages for people with skin infections.

Article Abstract

The construction of an efficient photothermal antibacterial platform is a promising strategy for the treatment of drug-resistant bacterial infections. Herein, through the introduction of excited-state intramolecular proton transfer to promote the photothermal effect, -(2,4-dihydroxybenzylidene)-4-aminophenol (DOA)-polyvinyl alcohol (PVA) systems (DPVA) can reach 55 °C within 10 s under irradiation. They show superior antibacterial behavior against drug-resistant bacteria and a therapeutic effect on infected skin wounds with only 100 s of irradiation, much faster than those of reported photothermal materials (5-10 min). This work provides a convenient approach to fabricate broad-spectrum antibacterial wound dressings for treating bacteria-infected wounds, greatly contributing to the design and applications of photothermal antibacterial platforms.

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Source
http://dx.doi.org/10.1039/d2tb02664cDOI Listing

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