A magnetic resonance imaging (MRI) scan was performed to rule out a sternal fracture in a woman in 30s. Short tau inversion recovery (STIR) coronal showed no signal change in the sternum but increased signal from the mediastinum to the anterior thoracic region. We could not detect significant findings until midway through the examination. T-weighted fat-suppressed images revealed a suspected left first costal cartilage injury at the end of the examination. In addition, three-dimensional gradient-recalled echo (3D GRE) T-weighted fat-suppressed images clearly revealed a lesion area with a high signal intensity in the costal cartilage and a low signal intensity in the surrounding tissue, and we diagnosed costal cartilage injury definitely. In case of MRI for posttraumatic chest pain, T-weighted fat-suppressed images with 3D GRE may be useful for the detection of lesion area.
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http://dx.doi.org/10.6009/jjrt.2023-1351 | DOI Listing |
J Orthop Case Rep
January 2025
Department of Orthopedic Surgery, National Hospital Organization Kyoto Medical Center. 1-1 Fukakusa-Mukaihatacho, Fushimi Ward, Kyoto city, Kyoto Prefecture, 612-8555, Japan.
Introduction: Despite the good clinical outcomes of osteochondral autograft transplantation (OAT), reports of re-arthroscopic findings after OAT have been limited to short-term, and there are no reports of findings after long-term follow-up. This is the first report that describes re-arthroscopic findings long-term after OAT.
Case Report: A male patient underwent OAT on the lateral femoral condyle (LFC) of the knee and lateral meniscus (LM) repair at the age of 45.
Osteochondral defects (OCD) pose a significant clinical challenge due to the limited self-repair capacity of cartilage, leading to pain, joint dysfunction, and progression to osteoarthritis. Cellular implantations of adult mesenchymal stem cells (MSCs) enhanced with treatment of factors, such as small molecule Kartogenin (KGN) to promote chondrogenic differentiation, are promising but these cells often encounter hypertrophy during differentiation, compromising long-term stability. Induced pluripotent stem cell-derived MSCs (iMSCs) offer greater proliferative and differentiation capacity than MSCs and may provide a superior source of cells for cartilage repair.
View Article and Find Full Text PDFIntroduction: Mesenchymal stem cell (MSC)-based therapies have emerged as a promising approach for treating articular cartilage injuries. However, enhancing the chondrogenic differentiation potential of MSCs remains a significant challenge. KDM6B, a histone demethylase that specifically removes H3K27me3 marks, is essential in controlling the maturation of chondrocytes.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
January 2025
Department of Trauma and Orthopedic Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Background: Rib and sternum fractures are common injuries associated with cardiopulmonary resuscitation (CPR). The fracture mechanism is either direct by application of force on sternum and anterior ribs or indirect by bending through compression of the thorax. The aim of this study was to determine morphologies of rib fractures after CPR and to reevaluate prior findings on fracture localisation, type and degree of dislocation.
View Article and Find Full Text PDFBiofabrication
January 2025
Department of Orthopaedics, Tangdu Hospital Fourth Military Medical University, 569 Xinsi Road, Baqiao District, Xi 'an City, Xi'an, Shaanxi, 710038, CHINA.
Three-dimensional (3D) bioprinting, an additive manufacturing technology, fabricates biomimetic tissues that possess natural structure and function. It involves precise deposition of bioinks, including cells, and bioactive factors, on basis of computer-aided 3D models. Articular cartilage injurie, a common orthopedic issue.
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