Serum aluminum concentrations were determined in ten healthy subjects treated with phenytoin 500 mg and with sucralfate and phenytoin in a crossover fashion. Each subject received four 1,000-mg sucralfate tablets between 8 AM and 10 PM one day before the study, and this was repeated during the study day. A total of eight doses of sucralfate was administered over the two-day period. Serum samples were drawn at 0, 2, 4, 8, 12, 24, 32, and 48 hours after administration. The areas under the serum aluminum concentration-time curves before and after sucralfate (mean +/- SD) were 496.0 +/- 80.9 and 770.9 +/- 146.6 hr-ng/mL, respectively. This increase is statistically significant (P less than .01), indicating that serum aluminum levels are elevated even after two days of treatment with sucralfate. The results from this study are not in agreement with the only other report on this subject.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/j.1552-4604.1987.tb02187.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Screening of Aluminum-Based MOFs for Effective In Situ Immobilization of Biomolecules.
Inorg Chem
January 2025
Institut Lavoisier de Versailles, UMR CNRS 8180, UVSQ, Université Paris-Saclay, 78035 Versailles, France.
An effective approach for the immobilization and protection of biological entities is their encapsulation via the in situ synthesis of metal-organic frameworks (MOFs). To ensure the preservation of the bioentities, mild synthetic conditions, including aqueous media and ambient conditions (temperature and pressure), are preferred. In this study, we investigated the synthesis of various aluminum polycarboxylate-based MOFs, including the fumarate, terephthalate, amino-terephthalate, and muconate forms of MIL-53(Al), as well as the MIL-110 and MIL-160 MOF types.
View Article and Find Full Text PDFA combination of gold nanoparticles and laser photobiomodulation to boost antioxidant defenses in the recovery of muscle injuries caused by Bothrops jararaca venom.
Lasers Med Sci
January 2025
Laboratory of Pathophysiology Experimental, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
Unlabelled: This study aimed to evaluate gold nanoparticles (GNPs) and photobiomodulation (PBM), associated with antibothropic serum (AS), to treat a muscle lesion induced by Bothrops jararaca venom.
Methods: 108 Swiss male mice were used, divided into nine groups (n = 12) with different combinations of treatments. Animals were inoculated with 250 µg of B.
Arterial blood gases and serum cortisol level as predictors for mortality in acute aluminum phosphide poisoned patients: A prospective cohort study.
Toxicol Rep
June 2025
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Egypt.
Aluminum phosphide (ALP) is an extremely toxic substance that causes significant morbidity and mortality. Early identification of patients at risk could improve their outcomes. Therefore, this study evaluated the role of serial arterial blood gases and serum cortisol levels in predicting outcomes in patients with acute ALP poisoning.
View Article and Find Full Text PDFAbnormal expression of miR-668-3p in non-small cell lung cancer patients and its correlation with serum-related tumor markers.
J Cardiothorac Surg
January 2025
Department of Oncology, The 969th Hospital of the PLA joint Logistics Support Force, No. 57, Aimin Street, Xincheng District, Hohhot City, Inner Mongolia Autonomous Region, 010051, China.
Background: The accuracy and reliability of identified biomarkers in differentiating early non-small cell lung cancer (NSCLC) remain suboptimal, thereby impeding the timely detection of NSCLC.The objective of this research is to examine the expression level and diagnostic utility of miR-668-3p in individuals with NSCLC, along with its effectiveness and predictive capacity in the combined diagnosis of early-stage NSCLC using serum markers.
Methods: The research included 117 NSCLC patients and 101 pulmonary nodule patients (controls).
Protective effects of polydatin amphiphilic chitosan nanocarriers against an aluminum chloride-induced model of Alzheimer's disease in rats: relevance to its anti-inflammatory and antioxidant effects.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Alzheimer's disease (AD) is the most frequent cause of dementia. Since there are complex pathophysiological mechanisms behind AD, and there is no effective treatment strategy, it is necessary to introduce novel multi-targeting agents with fewer side effects and higher efficacy. Polydatin (PD) is a naturally occurring resveratrol glucoside employing multiple mechanisms toward neuroprotection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!