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Medical Cannabis in the United States: Comparing 2017 and 2024 State Qualifying Conditions to the 2017 National Academies of Sciences Report.
Mayo Clin Proc Innov Qual Outcomes
April 2025
Department of Medical Education, Geisinger Commonwealth School of Medicine, Scranton, PA.
Objective: To compare the 2017 National Academies of Sciences, Engineering, and Medicine cannabis report to state medical cannabis (MC) laws defining approved qualifying conditions (QC) from 2017 and 2024 and to determine the evidence level of the QCs approved in each state.
Patients And Methods: The 2017 National Academies of Sciences (NAS) report assessed therapeutic evidence for over 20 medical conditions treated with MC. We identified the QCs of 38 states (including Washington DC) where MC was legal in 2024 and compared them to the QCs listed by these states in 2017.
Cannabis and liver transplant in the era of legalization: Effects of pre-transplant cannabis use on postoperative opioid use and transplant outcomes.
Liver Transpl
February 2025
University of California San Francisco Medical Center at Parnassus, Division of Gastroenterology and Hepatology.
Background: Cannabis use is increasing in the United States, including among liver transplant candidates. Although the anesthesia literature suggests an association between cannabis use and increased post-operative pain, the impact of cannabis use on post-liver transplant (LT) opioid use remains unknown. This study investigates changes in cannabis use at a transplant center over time, as well as the impact of cannabis use on post-LT opioid use, healthcare utilization, and mortality.
View Article and Find Full Text PDFMulti-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
medRxiv
February 2025
Department of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry, 10,231 of African ancestry, 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes. We replicated the well-known association at the locus (lead SNP: rs147144681, p =1.
View Article and Find Full Text PDFBackground: The purpose of the present study was to assess whether an association exists between cannabis use and nonunion among patients with acute scaphoid fractures initially treated nonoperatively.
Methods: Using the PearlDiver national data set (2010-2020), adult patients with a scaphoid fracture were identified. Patients initially treated with nonoperative management were selected, and 3 subgroups were defined: non-cannabis/non-tobacco (non-users), tobacco-only, cannabis-only.
What Are Tolerance Breaks and Why Do Young Adults Take Them? A Qualitative Investigation of Temporary Abstinence Breaks from Cannabis.
Cannabis
February 2025
Center for the Study of Health and Risk Behaviors, Department of Psychiatry and Behavioral Sciences, University of Washington.
Objective: This study investigated young adults' (YAs) experiences with tolerance breaks (temporary abstinence from cannabis; T-breaks).
Method: In Study 1, 15 YAs who used cannabis completed a qualitative interview. In Study 2, 66 YAs who used cannabis at least 2x/week completed online survey items assessing T-break familiarity, definitions, motivations, and experiences.
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