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Phenomenological Mapping: A Method For Understanding Pre-Reflective Consciousness.
Integr Psychol Behav Sci
December 2024
Universidad del Desarrollo, Santiago de Chile, Chile.
Exploring the nuanced and often elusive realm of pre-reflective consciousness presents a methodological challenge, as it involves capturing experiences that arise prior to reflective thought and language. This article introduces Phenomenological Mapping, an innovative research method designed to systematically study the pre-reflective dimensions of human experience. Grounded in the foundational theories of Edmund Husserl (2012), Maurice Merleau-Ponty (2013), and Martin Heidegger (1992, 2008), the approach also integrates contemporary perspectives from Dan Zahavi (1999, Contemporary Phenomenology and Qualitative Research 5(1), 1-17, 2021), Shaun Gallagher (2006, 2017), and Evan Thompson (2010, 2017).
View Article and Find Full Text PDFAssociation of plasma BDNF and MMP-9 levels with mild cognitive impairment: a matched case-control study.
Sci Rep
December 2024
Department of Public Health, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
The prevalence of Alzheimer's disease (AD) is on the rise globally, and everyone who develops AD eventually experiences mild cognitive impairment (MCI) first. Timely intervention at an early stage of the disease may mitigate disease progression. Recent studies indicate that BDNF and MMP-9 play a significant role in the pathogenesis of AD.
View Article and Find Full Text PDFManagement and outcomes among older adults with generalized epilepsy in routine clinical practice.
Epilepsia Open
December 2024
Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Generalized epilepsy is classically thought of as a disease of the young and adolescent, with rarely reported cases among older adults. We aimed to analyze management and outcomes in a population sparsely described in the literature through a retrospective single-center cohort design. After excluding individuals without follow-up, we identified 151 people ≥50 years at the time of electrographically confirmed generalized epilepsy.
View Article and Find Full Text PDFApplications and Future Prospects of Medical LLMs: A Survey Based on the M-KAT Conceptual Framework.
J Med Syst
December 2024
School of Basic Medical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, 310053, China.
The success of large language models (LLMs) in general areas have sparked a wave of research into their applications in the medical field. However, enhancing the medical professionalism of these models remains a major challenge. This study proposed a novel model training theoretical framework, the M-KAT framework, which integrated domain-specific training methods for LLMs with the unique characteristics of the medical discipline.
View Article and Find Full Text PDFTau, amyloid, iron, oligodendrocytes ferroptosis, and inflammaging in the hippocampal formation of aged rats submitted to an aerobic exercise program.
Brain Res
December 2024
Federal University of São Paulo, Paulista School of Medicine, Department of Physiology, Laboratory of Neurophysiology, São Paulo, Brazil.
Alzheimer's disease is a progressive neurodegenerative disease affecting memory, language, and thinking with no curative treatment. Symptoms appear gradually, and pathological brain changes may occur twenty years before the physical and psychological signs, pointing to the urgent development of preventive interventions. Physical activity has been investigated as a preventive tool to defeat the main biological features of AD: pathological amyloid protein plaques, tau tangles, myelin degeneration, and iron deposits in the brain.
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