A variety of technologies are emerging to help clinicians provide patient-specific diagnosis and therapies. This special edition of the Molecular Aspects of Medicine is a collection of mini reviews covering a broad range of topics, from systems to model patient variants and discover therapies (Microphysiological systems with patient derived tissue and CRISPR-humanized animal models), to new modalities in diagnostics and therapeutics (Extracellular Vesicles, RNA therapeutics, microbiome and molecular dynamics).
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| http://dx.doi.org/10.1016/j.mam.2023.101182 | DOI Listing |
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Regulation of metastatic organotropism.
Trends Cancer
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Herbert Irving Comprehensive Cancer Center, New York, NY, 10032, USA; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA; Division of Digestive and Liver Diseases, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:
Metastasis is responsible for most cancer-related deaths. Different cancers have their own preferential sites of metastases, a phenomenon termed metastatic organotropism. The mechanisms underlying organotropism are multifactorial and include the generation of a pre-metastatic niche (PMN), metastatic homing, colonization, dormancy, and metastatic outgrowth.
View Article and Find Full Text PDFMeasuring technology-facilitated sexual violence and abuse: a scoping review protocol of existing measurements.
BMJ Open
December 2024
School of Nursing and Midwifery, University of Birmingham, Birmingham, UK.
Introduction: Technology-facilitated sexual violence and abuse (TFSVA) refers to a range of behaviours in which digital technologies are used to facilitate both virtual and face-to-face sexual harm. The proliferation of smartphone usage and increasing internet penetration rates across the world have made it easier for individuals to become perpetrators and victims of TFSVA. Since empirical studies of TFSVA remain limited in the academic arena, and there is an absence of evidence to support the development of a standardised TFSVA measurement, this review aims to explore what TFSVA measurements are currently available and their potential use in measuring TFSVA.
View Article and Find Full Text PDFAdvanced technological approaches and market status analysis of xylose bioconversion and utilization: Xylooligosacharides and xylonic acid as emerging products.
Biotechnol Adv
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Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China; Jiangsu Province Key Laboratory of Green Bio-based Fuels and Chemicals, Nanjing 210037, China. Electronic address:
The efficient conversion of xylose is a short board of cask effect to lignocellulosic biorefining, by markedly affecting the total economic and environmental benefits. Based on a comprehensive analysis of the current commercial status of traditional xylose utilization and industrial technology development, this review outlines new technological avenues for the efficient utilization of xylose from lignocellulosic biomass, focusing on super prebiotic xylo-oligosaccharides and multifunctional platform compound xylonic acid. Firstly, the traditional products that can be derived from lignocellulosic xylose, including xylitol (447.
View Article and Find Full Text PDFRECENT FOCUS IN NON-SELEX-COMPUTATIONAL APPROACH FOR DE NOVO APTAMER DESIGN: A MINI REVIEW.
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Department of Biochemistry, Kampala International University-Western Campus, Ishaka, Uganda.
Aptamers, single-stranded nucleic acids that bind to specific targets with high affinity and specificity, hold significant promise in various biomedical and biotechnological applications. The traditional method of aptamer selection, SELEX (Systematic Evolution of Ligands by EXponential Enrichment) takes a lot of work and time. Recent advancements in computational methods have revolutionized aptamer design, offering efficient and effective alternatives.
View Article and Find Full Text PDFTesting the existence of waste Kuznets curve hypothesis in 45 emerging economies: Evidence from an e-waste panel data survey.
J Environ Manage
December 2024
School of Economics, Ocean University of China, No.238, Songling Road, Qingdao, 266100, China.
This study examines the Waste Kuznets Curve (WKC) hypothesis by integrating it with the Tapio decoupling model to explore the relationship between economic development and e-waste imports in 45 emerging economies from 2002 to 2022. The empirical results show that (1) the relationship between economic growth and e-waste imports exhibits an inverted U-shaped curve, with decoupling achieved when GDP per capita exceeds the WKC turning point of $10,755.23; (2) Emerging economies are categorized into six quadrants based on their e-waste decoupling status: high-income non-decoupling, low-income non-decoupling, low-income relative decoupling, high-income relative decoupling, low-income absolute decoupling, and high-income absolute decoupling; (3) Most emerging economies remain in low-income non-decoupling state, with only a few countries like China and Poland achieving high-income absolute decoupling.
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