AI Article Synopsis
- This research presents a technique using parahydrogen-induced polarization (PHIP) to enhance the observation of carbon-labeled metabolites through magnetic resonance imaging (MRI) for real-time monitoring inside the body.
- The method involves transferring parahydrogen-derived singlet order into carbon magnetization using adiabatic radio frequency sweeps at very low magnetic fields, resulting in substantial increases in nuclear spin polarization, sometimes exceeding 60%.
- Additionally, a new approach involving site-selective deuteration is introduced to improve the efficiency of polarization transfer by integrating deuterium into the molecular structure, minimizing relaxation effects from closely coupled nuclei.
Article Abstract
Magnetic resonance imaging of C-labeled metabolites enhanced by parahydrogen-induced polarization (PHIP) enables real-time monitoring of processes within the body. We introduce a robust, easily implementable technique for transferring parahydrogen-derived singlet order into C magnetization using adiabatic radio frequency sweeps at microtesla fields. We experimentally demonstrate the applicability of this technique to several molecules, including some molecules relevant for metabolic imaging, where we show significant improvements in the achievable polarization, in some cases reaching above 60% nuclear spin polarization. Furthermore, we introduce a site-selective deuteration scheme, where deuterium is included in the coupling network of a pyruvate ester to enhance the efficiency of the polarization transfer. These improvements are enabled by the fact that the transfer protocol avoids relaxation induced by strongly coupled quadrupolar nuclei.
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| http://dx.doi.org/10.1021/acs.jpclett.2c03785 | DOI Listing |
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