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Acellular fish skin grafts in diabetic foot ulcer care: Advances and clinical insights.
World J Diabetes
January 2025
Department of Nephrology, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie 551700, Guizhou Province, China.
Diabetic foot ulcers (DFUs) represents a significant public health issue, with a rising global prevalence and severe potential complications including amputation. Traditional treatments often fall short due to various limitations such as high recurrence rates and extensive resource utilization. This editorial explores the innovative use of acellular fish skin grafts as a transformative approach in DFU management.
View Article and Find Full Text PDFActive learning driven prioritisation of compounds from on-demand libraries targeting the SARS-CoV-2 main protease.
Digit Discov
January 2025
School of Natural and Environmental Sciences, Newcastle University Newcastle Upon Tyne NE1 7RU UK
FEgrow is an open-source software package for building congeneric series of compounds in protein binding pockets. For a given ligand core and receptor structure, it employs hybrid machine learning/molecular mechanics potential energy functions to optimise the bioactive conformers of supplied linkers and functional groups. Here, we introduce significant new functionality to automate, parallelise and accelerate the building and scoring of compound suggestions, such that it can be used for automated design.
View Article and Find Full Text PDFMuscular Performance of the Elbow Flexor and Extensor Muscles in Children With Myopathies: A Case-Control Study.
Physiother Res Int
January 2025
Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Background And Purpose: Children with myopathies often experience muscle weakness in their lower limbs. However, the upper limbs are also affected and, at the same time, play a key role in daily living activities as well as in transfers and assisted mobility using auxiliary devices. The objective was to assess the performance of the elbow flexor and extensor muscles through static and dynamic contractions in children with myopathies and in their typical peers.
View Article and Find Full Text PDFInvestigating nonlinear dynamic properties of an inertial sensor with rotational velocity-dependent rigidity.
Sci Rep
January 2025
Department of Mechanical Engineering, Faculty of Engineering, Urmia University, Urmia, Iran.
This study investigates the nonlinear dynamics of a system with frequency-dependent stiffness using a MEMS-based capacitive inertial sensor as a case study. The sensor is positioned directly on a rotating component of a machine and consists of a microbeam clamped at both ends by fixed supports with a fixed central proof mass. The nonlinear behavior is determined by electrostatic forces, axial and bending motion coupling, and frequency-dependent stiffness.
View Article and Find Full Text PDFActive vaccine safety surveillance in low- and middle-income countries: Challenges for vaccine manufacturers from emerging countries.
Vaccine
January 2025
Instituto Butantan, Sao Paulo, Brazil.
Developing Countries Vaccine Manufacturers Network (DCVMN) is an alliance of vaccine developers, manufacturers, and marketing authorization holders (MAHs) from low- and middle-income countries (LMICs) that plays a vital role in ensuring equitable, inclusive, accountable, and timely access to affordable, high-quality vaccines in these countries. Besides research and development, this network promotes manufacturing and global supply chains for effective strengthening of regulatory and pharmacovigilance activities. Traditionally, vaccine safety surveillance systems in LMICs rely on spontaneous reporting.
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