p p
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/tmj.2022.0491 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
iBCS: 4. Application of the Inhalation Biopharmaceutics Classification System to the Development of Orally Inhaled Drug Products.
Mol Pharm
March 2025
Merck & Co., Inc., Rahway, New Jersey 07065, United States.
This is the fourth paper in a series describing an inhalation biopharmaceutics classification system (iBCS), an initiative supported by the Product Quality Research Institute. The paper examines the application of the inhalation Biopharmaceutics Classification System (iBCS) through the drug discovery, development, and postapproval phases for orally inhaled drug products (OIDP) and for the development of generic OIDPs. We consider the implication of the iBCS class in terms of product performance and identify the practical gaps that must be filled to enable the classification system to be adopted into day-to-day practice.
View Article and Find Full Text PDFFemtosecond laser-ablative aqueous synthesis of multi-drug antiviral nanoparticles.
Nanomedicine (Lond)
March 2025
Department of Chemistry and The Institute for Laser, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Background: Nanomedicine offers a number of innovative strategies to address major public health burdens, including complex respiratory illnesses. In this work, we introduce a multi-drug nanoparticle fabricated using femtosecond laser ablation for the treatment of influenza, SARS-CoV-2, and their co-infections.
Methods: The SARS-CoV-2 antiviral, remdesivir; the influenza antiviral, baloxavir marboxil; and the anti-inflammatory, dexamethasone, were co-crystalized and then ablated in aqueous media using a femtosecond pulsed laser and subsequently surface modified with the cationic polymer, chitosan, or poly-d-lysine.
A population-based cohort study of perinatal mental illness following traumatic brain injury.
Epidemiol Psychiatr Sci
March 2025
Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Aims: To examine the risk of perinatal mental illness, including new diagnoses and recurrent use of mental healthcare, comparing women with and without traumatic brain injury (TBI), and to identify injury-related factors associated with these outcomes among women with TBI.
Methods: We conducted a population-based cohort study in Ontario, Canada, of all obstetrical deliveries to women in 2012-2021, excluding those with mental healthcare use in the year before conception. The cohort was stratified into women with no remote mental illness history (to identify new mental illness diagnoses between conception and 365 days postpartum) and those with a remote mental illness history (to identify recurrent illnesses).
'Too much, too little' - heat wave impact during pregnancy and the need for adaptation measures.
Glob Health Action
December 2025
Department of Epidemiology and Global Health, Medical Faculty, Umeå University, Umeå, Sweden.
The balls are rolling for climate change, with increasing vulnerability to women and children related to climate extreme events. Recent evidence has shown that acute exposure to heat wave during pregnancy can be associated with adverse health outcomes in childhood, with the risk being significantly higher among socially disadvantaged population, despite their lack of contribution to global carbon dioxide emissions and the rising global ambient temperature. This unequal impact requires utmost attention to develop tools, establish interdisciplinary teams, and to implement evidence-based interventions for the betterment of women and children in climate-vulnerable populations.
View Article and Find Full Text PDFInternal Validity and Reliability of the GAD-7 Test in Latin America.
Chronic Stress (Thousand Oaks)
March 2025
Laboratorio de Neurociencias y Psicología Experimental. Área de Farmacología. Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Generalized anxiety has significantly increased in the general population during and after the COVID-19 pandemic, highlighting the need for rapid screening tools. In this context, the present study analyzed the psychometric properties and internal consistency of the Generalized Anxiety Disorder Scale (GAD-7) in healthcare workers and the general population in Latin America. A cross-sectional e-health study was conducted, surveying 11,279 Latin Americans online using snowball sampling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!