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http://dx.doi.org/10.3389/fmicb.2023.1141016 | DOI Listing |
J Glob Health
January 2025
Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.
Background: Osteoporosis is a degenerative disease of bone metabolism. The epidemiology of osteoporosis varies by age, sex, and geography. There is a lack of information on the prevalence of osteoporosis among Chinese adults.
View Article and Find Full Text PDFFront Hum Neurosci
November 2024
The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Introduction: Brain cross-sectional images, tractography, and segmentation are valuable resources for neuroanatomical education and research but are also crucial for neurosurgical planning that may improve outcomes in cerebellar and brainstem interventions. Although ultrahigh-resolution 7-Tesla (7T) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) reveal such structural brain details in living or fresh unpreserved brain tissue, imaging standard formalin-preserved cadaveric brain specimens often used for neurosurgical anatomic studies has proven difficult. This study sought to develop a practical protocol to provide anatomic information and tractography results of an human brainstem-cerebellum specimen.
View Article and Find Full Text PDFContemp Clin Trials Commun
December 2024
GSK, Collegeville, PA, USA.
Background: The run-in period is an important element of randomized controlled trials, and is often used in respiratory disease trials. The design of the run-in period can greatly impact results and data interpretation, and as such should be designed carefully.
Methods: In this review, we describe the design of run-in periods across six phase 3A trials of triple therapy in asthma, and discuss how differences in run-in period design (specifically the duration, treatment, and reporting of run-in results) may have the potential to alter the interpretation of study outcomes.
Front Reprod Health
October 2024
Molecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, United States.
Muscle Nerve
January 2025
Grifols Bioscience Research Group, Research Triangle Park, North Carolina, USA.
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