Bier anemic spots, cyanosis, and urticaria-like eruption comprise the recently defined BASCULE syndrome. This rare and benign condition has been reported in approximately 15 individuals in the literature. We present three new cases of BASCULE syndrome occurring in adolescents with interesting associations.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926387PMC
http://dx.doi.org/10.1177/2050313X231152062DOI Listing

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[Translated article] Adult-Onset BASCULE Syndrome.

Actas Dermosifiliogr

September 2024

Servicio de Anatomía Patológica, Hospital Universitari General de Catalunya, Grupo Hospitalario Quirón Salud, Sant Cugat del Vallés, Barcelona, Spain.

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We describe an unusual presentation of Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome in a 15-year-old male, recalcitrant to low-dose anti-histamines, which subsequently responded to high-dose fexofenadine.

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Background: Bier anemic spots, cyanosis with urticaria-like eruption (BASCULE) syndrome is a recently described entity with episodic urticarial lesions and white anemic halos on a background of erythrocyanosis, commonly affecting the lower extremities. Possible association with autonomic dysfunction remains poorly understood. Existing publications are limited, but the condition is suggested as highly underrecognized.

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