AI Article Synopsis
- Ectopic secretion of parathyroid hormone (PTH) can cause hypercalcemia, a rare occurrence in patients with cancer, as demonstrated in a 56-year-old woman with endometrial carcinoma.
- The patient's life-threatening hypercalcemia was linked to PTH production by the tumor, and was alleviated following cytoreductive surgery (CRS) that confirmed the cancer as MMR-deficient.
- Despite chemotherapy and immunotherapy, the woman's condition worsened, leading to multiple organ failure and her death roughly five months after the surgery, marking a unique case of hypercalcemia from a specific type of cancer with an unusual complication.
Article Abstract
Ectopic secretion of parathyroid hormone (PTH) is a rare cause of hypercalcemia in malignancy patients. A 56-year-old woman with life-threatening hypercalcemia was caused by poorly-differentiated endometrial carcinoma secreting PTH with concomitant nodular goiter mimic parathyroid tumors. The elevated level of PTH and calcium decreased immediately after cytoreductive surgery (CRS). The pathology confirmed mismatch repair (MMR)-deficient endometrial carcinoma with PTH expression. The patient received four-course chemotherapy and one-course immunotherapy after CRS. The disease progression led to multiple organ failure and death about five months after CRS. To our knowledge, this is the first case of hypercalcemia caused by MMR-deficient endometrial carcinoma with ectopic PTH secreting and the first report of malignancy associated hypercalcemia complicated with nodular goiter.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927209 | PMC |
| http://dx.doi.org/10.3389/fendo.2023.1125822 | DOI Listing |
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