Alpha-gal syndrome (AGS) in a glaucoma suspect with narrow iridocorneal angles.

Am J Ophthalmol Case Rep

Institute for Vision Research, University of Iowa, Iowa City, IA, 52242, USA.

Published: March 2023

AI Article Synopsis

  • Alpha-gal syndrome (AGS) is a serious allergy to certain carbohydrates found in non-primate mammals, requiring patients to avoid ophthalmic drugs with animal-derived ingredients.
  • A 59-year-old woman with AGS, diagnosed after a tick bite, successfully underwent laser iridotomy for glaucoma using safe, non-animal-derived medications.
  • It’s crucial for ophthalmologists to recognize AGS and select appropriate medications to prevent severe allergic reactions in affected patients.

Article Abstract

Purpose: Alpha-gal syndrome (AGS) is an allergy to non-primate mammalian carbohydrate (galactose-alpha-1,3-galactose) which may cause anaphylaxis. Allergic patients must avoid ophthalmic drugs containing animal-derived ingredients.

Observations: We report a 59-year-old non-Hispanic white woman who was referred for a glaucoma evaluation. She had been diagnosed with AGS after a tick bite in 2017. Ophthalmic exam revealed potentially occludable, narrow iridocorneal angles and laser iridotomy was recommended. Prior to performing the iridotomy, we investigated the ophthalmic medications required for the procedure to identify options that are free of animal-derived products and safe to use. Laser iridotomy was performed without complications or allergy to medications.

Conclusions: Ophthalmologists need to be aware of both the presence of AGS as well as the identity of ophthalmic medications that are safe to use in patients with this condition to avoid potentially lethal allergic responses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926184PMC
http://dx.doi.org/10.1016/j.ajoc.2023.101811DOI Listing

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