AI Article Synopsis
- The classical model of the basal ganglia involves direct pathway striatal projection neurons (dSPNs) regulating motor function by projecting to specific regions, but recent findings reveal they also have collaterals in the globus pallidus externus (GPe).
- Using advanced techniques like in vivo optical and chemogenetic tools, researchers investigated the role of these collaterals in motor function, discovering that they transmit motor-related information to the GPe.
- Inhibiting the activity of dSPN GPe terminals negatively affects motor activity by influencing Npas1 neurons, suggesting that these collaterals work together with traditional pathways to enhance motor control by modulating feedback signals.
Article Abstract
In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also possess "bridging" collaterals within the globus pallidus (GPe), yet the significance of these collaterals for behavior is unknown. Here we use in vivo optical and chemogenetic tools combined with deep learning approaches to dissect the roles of bridging collaterals in motor function. We find that dSPNs projecting to the SNr send synchronous motor-related information to the GPe via axon collaterals. Inhibition of native activity in dSPN GPe terminals impairs motor activity and function via regulation of pallidostriatal Npas1 neurons. We propose a model by which dSPN GPe collaterals ("striatopallidal Go pathway") act in concert with the canonical terminals in the SNr to support motor control by inhibiting Npas1 signals going back to the striatum.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934763 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-2524816/v1 | DOI Listing |
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