AI Article Synopsis
- The study aimed to compare the planning effectiveness of HyperArc™-based stereotactic radiosurgery versus CyberKnife® M6 in treating single and multiple cranial metastases.
- Researchers analyzed 51 treatment plans using both systems, focusing on dosimetric parameters and treatment plan quality for the target volumes and surrounding organs at risk.
- Results showed that while both techniques covered target volumes similarly, HyperArc demonstrated better brain sparing, making it potentially more suitable for multiple cranial metastases and larger single lesions compared to CyberKnife.
Article Abstract
Purpose: The purpose of this study was to compare the planimetric capacities between HyperArc™-based stereotactic radiosurgery and robotic radiosurgery system-based planning using CyberKnife® M6 for single and multiple cranial metastases.
Materials And Methods: We evaluated 51 treatment plans for cranial metastases, including 30 patients with a single lesion and 21 patients with multiple lesions, treated with the CyberKnife® M6. These treatment plans were optimized using the HyperArc™ (HA) system with the TrueBeam. The comparison of the quality of the treatment plans between the two treatment techniques (CyberKnife and HyperArc) was performed using the Eclipse treatment planning system. Dosimetric parameters were compared for target volumes and organs at risk.
Results: Coverage of the target volumes was equivalent between the two techniques, whereas median Paddick conformity index and median gradient index for all target volumes were 0.9 and 3.4, respectively for HyperArc plans, and 0.8 and 4.5 for CyberKnife plans (P<0.001). The median dose of gross tumor volume (GTV) for HyperArc and CyberKnife plans were 28.4 and 28.8, respectively. Total brain V18Gy and V12Gy-GTVs were 11cm and 20.2cm for HyperArc plans versus 18cm and 34.1cm for CyberKnife plans (P<0.001).
Conclusion: The HyperArc provided better brain sparing, with a significant reduction in V12Gy and V18Gy, associated with a lower gradient index, whereas the CyberKnife gave a higher median GTV dose. The HyperArc technique seems to be more appropriate for multiple cranial metastases and for large single metastatic lesions.
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| http://dx.doi.org/10.1016/j.canrad.2022.08.007 | DOI Listing |
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