AI Article Synopsis
- Pregnancy starts when a tiny embryo attaches to the mother’s womb, which helps keep both the baby and the mother healthy.
- New research shows that taking care of this early stage can help prevent health problems for both the baby and the mom later on.
- The article talks about how different parts of the mother’s body, like the endometrium and myometrium, work together to help the baby grow and how tiny bacteria in the womb can also affect pregnancy.
Article Abstract
Pregnancy is established during the periconceptional period as a continuum beginning with blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and placenta formation. This period sets the foundation for the child and mother's health during pregnancy. Emerging evidence indicates that prevention of downstream pathologies in both the embryo/newborn and pregnant mother may be possible at this stage. In this review, we discuss current advances in the periconceptional space, including the preimplantation human embryo and maternal endometrium. We also discuss the role of the maternal decidua, the periconceptional maternal-embryonic interface, the dialogue between these elements, and the importance of the endometrial microbiome in the implantation process and pregnancy. Finally, we discuss the myometrium in the periconceptional space and review its role in determining pregnancy health.
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| http://dx.doi.org/10.1152/physrev.00050.2021 | DOI Listing |
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