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Evaluation of a Hospitalized Pediatric COVID-19 Cohort from Indian National Clinical Registry of COVID-19. | LitMetric

AI Article Synopsis

  • The study assessed factors linked to mortality in hospitalized COVID-19 patients aged 0-18 across 42 centers in India from September 2020 to February 2022.
  • Out of 1,244 enrolled patients, 6.2% experienced in-hospital mortality, with infants having the highest death rate; common symptoms included fever, and 21% had at least one comorbidity.
  • Results indicated that altered sensorium, severe illness upon admission, and malignancy significantly increased the likelihood of death, while malnutrition did not impact outcomes, showing COVID-19 tends to be milder in children than in adults.

Article Abstract

Objective: To evaluate the factors associated with mortality of a multicentric cohort of hospitalized COVID-19 patients, 0-18 y old, from 42 centers across India.

Methods: The National Clinical Registry for COVID-19 (NCRC) is an on-going prospective data collection platform enrolling COVID-19 patients diagnosed by real-time PCR or rapid antigen test. The data are collected in prestructured e-capture forms. The sociodemographic, clinical, laboratory, and hospital outcome data from 1 September 2020 to 20 February 2022 were analyzed.

Results: Of the 1244 enrolled hospitalized COVID-19 patients aged 0-18 y, 98 and 124 were infants and neonates, respectively. Only 68.6% children were symptomatic at admission, with fever being the most common symptom. Diarrhea, rash, and neurological symptoms were also noted. At least 1 comorbidity was present in 260 (21%) children. The in-hospital mortality rate was 6.2% (n = 67), the highest in infants (12.5%). Altered sensorium (aOR: 6.8, CI: 1.9, 24.6), WHO ordinal scale ≥ 4 at admission (aOR: 19.6, CI: 8.0, 47.8), and malignancy (aOR: 8.9, 95% CI: 2.4, 32.3) were associated with higher odds of death. Malnutrition did not affect the outcome. Mortality rates were similar across the three waves of the pandemic, though a significant shift towards the under-five group was observed in the third wave.

Conclusion: This multicentric cohort of admitted Indian children showed that the COVID-19 was milder in children than adults, and the pattern was consistent across all waves of the pandemic.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933031PMC
http://dx.doi.org/10.1007/s12098-022-04449-wDOI Listing

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