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Recurrent intrathecal catheter-tip granuloma formation on a replaced system delivering low dose/concentration fentanyl and bupivacaine: a case report.
Reg Anesth Pain Med
November 2024
Department of Anesthesiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Background: Intrathecal drug delivery (IDD) is a well-established treatment modality for refractory chronic pain. Intrathecal catheter-tip granuloma (ICTG) formation is a known possible complication of opiate IDD and is likely triggered by mast cell degranulation. The use of low concentration and dosage of opioids that do not induce mast cell degranulation has been advised to mitigate the risk of ICTG formation.
View Article and Find Full Text PDFBackground: The reported prevalence of neuropathic pain in the general population in Germany is from 6.9% to 10%. There are both medical and surgical treatment options.
View Article and Find Full Text PDFIntrathecal Immunoselective Nanopheresis for Alzheimer's Disease: What and How? Why and When?
Int J Mol Sci
October 2024
Departamento de Medicina, Facultad de Ciencias de la Salud, Universidad de Oviedo, ES-33006 Oviedo, Spain.
Article Synopsis
- Nanotechnology is revolutionizing treatment for brain disorders through advanced drug delivery systems, particularly intrathecal immunoselective nanopheresis designed to target beta-amyloid in Alzheimer's disease.
- This review explores how intrathecal immunoselective nanopheresis works, its advantages, clinical implications, and emphasizes patient selection and timing for effective Alzheimer's treatment.
- The text also discusses potential limitations of this method, alternative therapeutic targets aside from beta-amyloid, and future directions for immunoselective nanopheresis research.
Density and Time Characteristics of CSF-venous fistulas on CT myelography in Patients with Spontaneous Intracranial Hypotension.
AJNR Am J Neuroradiol
September 2024
From the Department of Radiology and Oncology of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil (D.G.L.E.), Departamento de Radiologia e Centro de Medicina Intervencionista, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil (D.G.L.E.), Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil (D.G.L.E.) and Duke University Medical Center, Durham, NC, United States of America (T.J.A., P.G.K.).
Article Synopsis
- This study investigates factors affecting the visibility of CSF-venous fistulas (CVF) on specialized myelographic imaging, focusing on timing of imaging and contrast density.
- A cohort of 24 patients with spontaneous intracranial hypotension underwent 34 CT myelographies to analyze the relationship between contrast density in the subarachnoid space and visibility of CVFs.
- Results indicate that higher contrast density significantly correlates with better visibility of CVFs, whereas the timing of imaging does not have a significant impact on their visibility.
Gene therapy for the leukodystrophies: From preclinical animal studies to clinical trials.
Neurotherapeutics
July 2024
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:
Leukodystrophies are progressive single gene disorders affecting the white matter of the brain. Several gene therapy trials are in progress to address the urgent unmet need for this patient population. We performed a comprehensive literature review of all gene therapy clinical trials listed in www.
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