Background: The risk of fatal infection and death from Coronavirus disease 2019 (COVID-19) exposure increases in the elderly and those with coexisting illnesses such as cardiovascular disease, diabetes, cancer, obesity, and hypertension. The COVID-19 vaccine's efficacy and safety have been supported by numerous research. However, data from the Ministry of Health of Indonesia revealed that the elderly in North Jakarta had a reclining interest in receiving a booster dose. This research aimed to assess the perception of the elderly living in North Jakarta related to supporting and inhibiting factors in accepting the COVID-19 booster vaccination.
Methods: This qualitative research used a grounded theory design. It was conducted from March to May 2022, and data were gathered in North Jakarta's numerous districts through in-depth interviews until saturation was reached. Furthermore, data were validated using member checking, source triangulation to families of elderly, and vaccination doctors. They were processed to produce transcripts, codes, and finalized themes.
Results: Booster vaccination in the elderly was supported by 12 out of 15 informants, and the rest did not agree. The supporting factors include health, family, peer support, doctors, government, administrative requirements, endemic transformation, booster choice, and media coverage. Meanwhile, the inhibiting factors include hoaxes, concerns over the vaccine's safety and efficacy, political issues, family, and comorbidities.
Conclusions: Most of the elderly displayed positive attitudes concerning booster shots, but it was discovered that some barriers need to be removed.
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http://dx.doi.org/10.18549/PharmPract.2022.4.2748 | DOI Listing |
JMIR Form Res
January 2025
Department of Medical and Clinical Psychology, Center of Research on Psychological Disorders and Somatic Diseases (CoRPS), Tilburg University, Tilburg, the Netherlands, 31 134662142.
Background: Health-related data from technological devices are increasingly obtained through smartphone apps and wearable devices. These data could enable physicians and other care providers to monitor patients outside the clinic or assist individuals in improving lifestyle factors. However, the use of health technology data might be hampered by the reluctance of patients to share personal health technology data because of the privacy sensitivity of this information.
View Article and Find Full Text PDFMol Ther
January 2025
Department of Orthopaedic surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Tumor necrosis factor receptor-associated factor 1 (TRAF1) is a crucial signaling adaptor involved in multiple cellular events. However, its role in regulating osteoclastogenesis and energy metabolism remains unclear. Here, we report that TRAF1 promotes osteoclastogenesis and oxidative phosphorylation (OXPHOS).
View Article and Find Full Text PDFEnviron Microbiome
January 2025
Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Background: Recovery of degraded coral reefs is reliant upon the recruitment of coral larvae, yet the mechanisms behind coral larval settlement are not well understood, especially for non-acroporid species. Biofilms associated with reef substrates, such as coral rubble or crustose coralline algae, can induce coral larval settlement; however, the specific biochemical cues and the microorganisms that produce them remain largely unknown. Here, we assessed larval settlement responses in five non-acroporid broadcast-spawning coral species in the families Merulinidae, Lobophyllidae and Poritidae to biofilms developed in aquaria for either one or two months under light and dark treatments.
View Article and Find Full Text PDFSci Rep
January 2025
School of Stomatology, Bengbu Medical University, No. 2600 Donghai Road, Bengbu, 233030, China.
Tongue squamous cell carcinoma (TSCC) is a common malignant oral cancer characterized by substantial invasion, a high rate of lymph node and distant metastasis, and a high recurrence rate. This study aims to provide new ideas for the diagnosis and treatment of TSCC patients by exploring the related mechanisms that affect the migration and invasion of TSCC and inhibit the migration and spread of cancer cells. The results indicated the rate of high expression of IL-17 in cancer tissues was greater than that in tongue tissues, and the expression of IL-17 was related to the TNM stage.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Pathology, Division of Microbiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375, Wroclaw, Poland.
The process of viral entry into host cells is crucial for the establishment of infection and the determination of viral pathogenicity. A comprehensive understanding of entry pathways is fundamental for the development of novel therapeutic strategies. Standard techniques for investigating viral entry include confocal microscopy and flow cytometry, both of which provide complementary qualitative and quantitative data.
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