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Efficacy of Janus kinase inhibitors in the treatment of psoriasiform atopic dermatitis.
Clin Exp Dermatol
September 2024
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Atopic dermatitis (AD) is a common inflammatory skin disease with multiple clinical manifestations. Among AD phenotypes, psoriasiform AD shows the coexistence of eczematous itching lesions in flexural areas with psoriasiform plaques. The use of anti-interleukin (IL)-4 and anti-IL-13 in psoriasiform AD may lead to therapeutic failure or worsening of manifestations.
View Article and Find Full Text PDFParadoxical tralokinumab-induced psoriasis in a patient with atopic dermatitis.
J Dermatolog Treat
December 2023
Department of Dermatology, Venereology and Allergology, Helios St. Elisabeth Hospital Oberhausen, University of Witten/Herdecke, Oberhausen, Germany.
Article Synopsis
- Psoriasis and atopic dermatitis (AD) can coexist in patients, contrary to the belief that they are opposing diseases, especially with modern targeted therapies.
- Treatment with anti-IL-13 antibody tralokinumab led to the development of psoriasis vulgaris in a 36-year-old male patient who had severe intrinsic AD, highlighting unexpected complications from such treatments.
- This case indicates that both dual and selective IL-13 inhibition can disrupt immune balance, resulting in paradoxical psoriasis, but there are currently no clinical guidelines to predict this outcome in patients receiving biologic therapies.
Coexistence of psoriasiform stratum corneum and underlying lichenoid features in skin biopsies of cutaneous reactions to anti-PD1.
J Cutan Pathol
May 2023
Dermatology Department, Hospital Universitario de la Princesa, Madrid, Spain.
Acral keratoses and leucocytoclastic vasculitis occurring during treatment of essential thrombocythaemia with hydroxyurea.
Clin Exp Dermatol
March 2016
Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Hydroxyurea is used in essential thrombocythaemia to lower thromboembolic risk. Cutaneous adverse effects from hydroxyurea are diverse. Small vessel vasculitis has been rarely reported, and the coexistence of several different morphologies has not been described.
View Article and Find Full Text PDFHistopathological patterns indicative of distinct adverse drug reactions.
Chem Immunol Allergy
September 2012
Dermatopathology, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Histologically, drug eruptions may present virtually all patterns of inflammation in the skin, including spongiotic, lichenoid and psoriasiform dermatitis as well as vasculitis or panniculitis. Drug reactions may mimic specific skin diseases such as lupus erythematosus, lichen planus or lymphoma. While a single drug may cause a wide range of reaction patterns, no reaction pattern is specific for a certain drug.
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