This opinion piece considers the construct of tolerance of uncertainty and suggests that it should be viewed in the context of three psychological factors: uncertainty aversion, uncertainty interpretation, and uncertainty determinability. Uncertainty aversion refers to a dislike of situations in which the outcomes are not deterministic and is similar to conventional conceptions of (in)tolerance of uncertainty. Uncertainty interpretation refers to the extent to which variability in an observed outcome is interpreted as random fluctuation around a relatively stable base-rate versus frequent and rapid changes in the base-rate. Uncertainty determinability refers to the (actual or perceived) capacity of the individual to generate any meaningful expectancy of the uncertain outcome, which may be undeterminable if predictions are updated too quickly. We argue that uncertainty interpretation and determinability are psychological responses to the experience of probabilistic events that vary among individuals and can moderate negative affect experienced in response to uncertainty. We describe how individual differences in basic parameters of associative learning (modelled by a simple learning window) could lead to this variation. To explain these hypotheses, we utilise the distinction between aleatory uncertainty (the inherent unpredictability of individual stochastic events) and epistemic uncertainty (obtainable knowledge that the individual lacks or perceives to be lacking). We argue that when expectancies are updated quickly, epistemic uncertainty will dominate the individual's representation of the events around them, leading to a subjective experience of the world as one that is volatile and unpredictable.
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http://dx.doi.org/10.3758/s13415-023-01068-6 | DOI Listing |
J Fam Psychol
January 2025
Department of Social and Health Sciences, Bar-Ilan University.
Subjective views of aging (VoA) play a crucial role in shaping individuals' physical, mental, and overall well-being. While past research has primarily focused on individual perspectives, recent literature suggests the development of VoA within interpersonal relationships. This study introduces a new scale, the Views of Couple Joint Aging (VoCJA), examining VoA related to the aging process within couple partnerships.
View Article and Find Full Text PDFAm J Manag Care
December 2024
GRAIL, Inc., 1525 O'Brien Dr, Menlo Park, CA 94025. Email:
Objectives: Multicancer early detection (MCED) testing could result in earlier cancer diagnosis, thereby improving survival and reducing treatment costs. This study evaluated the cost-effectiveness of MCED testing plus usual care (UC) screening while accounting for the impact of clinical uncertainty and population heterogeneity for an MCED test with broad coverage of solid cancer incidence.
Study Design: Cost-effectiveness analysis of MCED testing plus UC vs UC alone in an adult population in the US.
J Hand Surg Am
January 2025
Division of Hand Surgery, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN; Department of Orthopedic Surgery, Clinical Investigation Facility, Travis Air Force Base, CA. Electronic address:
Purpose: The benefits of upper-extremity reconstructive surgery for patients with spastic deformities are well documented, but a small portion of eligible patients undergo surgery. We sought to determine perceptions of upper-extremity reconstructive surgery among brain injury patients and nonsurgical providers to identify potential barriers to surgical evaluation.
Methods: Electronic medical records at a referral center were reviewed for patients diagnosed with upper limb spasticity following brain injury.
J Chem Phys
January 2025
Department of Applied Physics, Aalto University, P.O. Box 11000, FI-00076 Aalto, Finland.
Active learning (AL) has shown promise to be a particularly data-efficient machine learning approach. Yet, its performance depends on the application, and it is not clear when AL practitioners can expect computational savings. Here, we carry out a systematic AL performance assessment for three diverse molecular datasets and two common scientific tasks: compiling compact, informative datasets and targeted molecular searches.
View Article and Find Full Text PDFCurr Opin Urol
December 2024
Division of Urologic Oncology.
Purpose Of Review: This review addresses the evolving role of metastasis-directed therapy (MDT) in the management of oligometastatic and oligoprogressive renal cell carcinoma (RCC). With advances in both surgical techniques and stereotactic ablative radiotherapy (SABR), it is timely to explore how MDT can improve patient outcomes in these distinct disease states. The review highlights the potential of MDT to delay systemic therapy and improve quality of life while noting the lack of randomized clinical trial data guiding its use.
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