The identification of animal behavior in video is a critical but time-consuming task in many areas of research. Here, we introduce DeepAction, a deep learning-based toolbox for automatically annotating animal behavior in video. Our approach uses features extracted from raw video frames by a pretrained convolutional neural network to train a recurrent neural network classifier. We evaluate the classifier on two benchmark rodent datasets and one octopus dataset. We show that it achieves high accuracy, requires little training data, and surpasses both human agreement and most comparable existing methods. We also create a confidence score for classifier output, and show that our method provides an accurate estimate of classifier performance and reduces the time required by human annotators to review and correct automatically-produced annotations. We release our system and accompanying annotation interface as an open-source MATLAB toolbox.
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http://dx.doi.org/10.1038/s41598-023-29574-0 | DOI Listing |
Background: Alzheimer's disease (AD) agitation is a distressing neuropsychiatric symptom characterized by excessive motor activity, verbal aggression, or physical aggression. Agitation is one of the causes of caregiver distress, increased morbidity and mortality, and early institutionalization in patients with AD. Current medications used for the management of agitation have modest efficacy and have substantial side effects.
View Article and Find Full Text PDFBackground: The increased incidence of Alzheimer's disease (AD) rate represent an unmet medical need and thus critical for the development of novel molecular therapeutics. Recent work focusing on patients with apoE4 alleles has highlighted the association of brain cholesterol dysregulation with elevated pathological burden and neurodegeneration. These studies have highlighted the importance of the nuclear receptor Liver X receptor (LXR) for developing AD therapies.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Iowa, Iowa City, IA, USA.
Background: Nursing home (NH) residents with dementia commonly experience mealtime behaviors that negatively impact nutrition and function. Residents do not receive person-centered mealtime care (PCMC) due to multilevel factors one prioritized modifiable factor is lack of effective PCMC programs. This study aimed to develop a PCMC program and test its feasibility, acceptability, usefulness and preliminary efficacy.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hanyang University, Seoul, Seoul, Korea, Republic of (South).
In the treatment of Alzheimer's disease (AD), traditional 40Hz gamma wave stimulation, while effective in improving cognitive function, has been limited by the lengthy duration of treatment. To address this, our study sought to enhance the time efficiency of 40Hz stimulation by utilizing intermittent theta-burst stimulation (iTBS) as a pretreatment. Experiments were conducted on AD mouse models, divided into four groups: no stimulation, 40Hz stimulation only, iTBS stimulation only, and combined iTBS and 40Hz stimulation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Georgia Institute of Technology, Atlanta, GA, USA.
Background: Chronic stress promotes life-long risk for neuropsychiatric decline by increasing neuroinflammation and disrupting synaptic health and plasticity. Our lab and others have recently demonstrated that non-invasive gamma sensory stimulation (flicker) modulates immune signaling, restores microglial function, and improves cognitive performance in mouse models of Alzheimer's disease (AD). However, no research to date has studied the effects of flicker in the context of stress.
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