AI Article Synopsis

  • Researchers investigated the characteristics and frequency of oxyntic gland neoplasms (OGNs) by analyzing data from patients diagnosed with OGN at an internal medicine clinic, finding an occurrence rate of 0.36% from a total of 7,488 patients.
  • Out of 30 confirmed OGN lesions in 27 patients, a significant number occurred in non-atrophied stomach regions, with some patients not having any history of Helicobacter pylori infection.
  • The study concluded that the prevalence of OGN is higher than previously believed and noted that specific small lesions in the stomach can be endoscopically treated, with no recurrences reported during follow-up.

Article Abstract

Objective We explored the clinicopathological characteristics and disease frequency of oxyntic gland neoplasms (OGNs). Methods We retrospectively evaluated the data of patients pathologically diagnosed with OGN at an internal medicine clinic. Patients A total of 13,240 upper gastrointestinal endoscopies were performed on 7,488 patients between December 1, 2017, and March 31, 2021. Results We identified 27 patients with 30 histopathologically confirmed OGNs, yielding a disease frequency of 0.36% (27/7,488). Furthermore, multiple simultaneous lesions were found in 3 of 27 patients (11%). One (3.3%) of the 30 lesions was present in the antrum, whereas the remaining lesions occurred in the body of the stomach. Nine (33%) of the 27 patients had no history of Helicobacter pylori infection, whereas the remaining 18 (67%) were either currently or had been previously infected. Nevertheless, 27/30 lesions (90%) still occurred in non-atrophied regions. After endoscopic treatment, a histopathological examination of the resected specimens revealed submucosal infiltration in 8 (44%) of the 18 lesions; however, none of the lesions showed submucosal desmoplasia. For all patients with submucosal involvement, only observation was performed. There were no recurrent lesions found on follow-up. Conclusion The period prevalence of OGN was 0.36%, which is much higher than previously reported. The discovery of a small submucosal appearing lesion with a faded yellow or white color and dilated microvasculature, especially in a non-atrophic area of the stomach, should raise suspicion for an OGN, which can be endoscopically managed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602823PMC
http://dx.doi.org/10.2169/internalmedicine.0552-22DOI Listing

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