AI Article Synopsis
- Granulomatosis with polyangiitis (GPA) is an autoimmune disease that leads to granuloma formation and affects small to medium-sized blood vessels, primarily impacting respiratory and renal functions.
- A case study highlights a 36-year-old man who first showed symptoms like ear pain, hearing loss, and facial paralysis, resulting in a delayed GPA diagnosis.
- Treatment with cyclophosphamide and methylprednisolone improved his symptoms, suggesting that otologic symptoms can sometimes be the first sign of GPA, warranting thorough evaluation rather than assumption of common ear issues.
Article Abstract
Granulomatosis with polyangiitis (GPA) is a chronic and systematic autoimmune condition characterized by granuloma formation and necrotizing vasculitis of small to medium-sized vessels. GPA initially presents itself as respiratory and renal symptoms. Although temporal bone involvement is not uncommon, an otologic disorder is rarely the initial symptom. We present a case of a 36-year-old man who presented with unilateral ear pain, hearing loss, and facial palsy. After a series of diagnostics and temporal bone and chest imaging, he was diagnosed with GPA with multiorgan involvement. Cyclophosphamide and methylprednisolone relieved the patient's ear pain and partially improved his hearing, facial palsy, and overall clinical condition. Although uncommon, systemic GPA may cause initial otologic symptoms and should not be dismissed as a possible cause of an otologic disease resistant to standard therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352694 | PMC |
| http://dx.doi.org/10.7874/jao.2022.00311 | DOI Listing |
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