AI Article Synopsis
- A new dehydrative amidation catalyst has been created, utilizing a thianthrene boron acid structure, which is available for commercial use.
- This catalyst demonstrates strong effectiveness in reacting with a variety of carboxylic acid substrates, including both aliphatic compounds and less reactive aromatic ones.
- It is particularly useful for modifying bioactive or clinical molecules that contain carboxylic acid groups.
Article Abstract
A commercially available and versatile dehydrative amidation catalyst, featuring a thianthrene boron acid structure, has been developed. The catalyst shows high catalytic activity to both aliphatic and less reactive aromatic carboxylic acid substrates, including several bioactive or clinical molecules with a carboxylic acid group.
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| http://dx.doi.org/10.1021/acs.joc.2c02515 | DOI Listing |
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