Euodiae Fructus, referred to as "Wuzhuyu" in Chinese, has been used as local and traditional herbal medicines in many regions, especially in China, Japan and Korea, for the treatment of gastrointestinal disorders, headache, emesis, aphtha, dermatophytosis, dysentery, etc. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this plant has been focused on the different structural types of alkaloids like evodiamine, rutaecarpine, dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone, which exhibit a wide range of pharmacological activities in preclinical models, such as anticancer, antibacterial, anti-inflammatory, anti-cardiovascular disease, etc. This review summarizes the up-to-date and comprehensive information concerning the botany, traditional uses, phytochemistry, pharmacology of Euodiae Fructus together with the toxicology and quality control, and discusses the possible direction and scope for future research on this plant.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931992 | PMC |
| http://dx.doi.org/10.1007/s13659-023-00369-0 | DOI Listing |
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Article Synopsis
- A new ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed for analyzing chemical components in Euodiae Fructus.
- The study optimized various chromatographic and mass spectrometry conditions, ultimately using specific columns and mobile phases for effective separation and detection.
- A total of 92 compounds, including 33 alkaloids and 23 flavonoids, were characterized, with 11 being newly identified, advancing understanding of Euodiae Fructus's chemical profile and supporting quality control efforts.
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