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Altered controllability of white matter networks and related brain function changes in first-episode drug-naive schizophrenia. | LitMetric

Altered controllability of white matter networks and related brain function changes in first-episode drug-naive schizophrenia.

Cereb Cortex

Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, China.

Published: February 2023

AI Article Synopsis

  • - The study investigates how changes in brain connectivity impact functional dynamics in schizophrenia, utilizing network control theory with 140 drug-naive patients and 119 healthy controls.
  • - Drug-naive schizophrenia patients showed reduced average controllability (AC) in brain regions linked to the default mode and visual networks, while having increased AC in the somatomotor network compared to healthy controls.
  • - The findings reveal that longer durations of untreated psychosis correlate with decreased AC, particularly affecting the visual and default mode networks, emphasizing the link between structural changes and functional dysfunctions in schizophrenia.

Article Abstract

Understanding how structural connectivity alterations affect aberrant dynamic function using network control theory will provide new mechanistic insights into the pathophysiology of schizophrenia. The study included 140 drug-naive schizophrenia patients and 119 healthy controls (HCs). The average controllability (AC) quantifying capacity of brain regions/networks to shift the system into easy-to-reach states was calculated based on white matter connectivity and was compared between patients and HCs as well as functional network topological and dynamic properties. The correlation analysis between AC and duration of untreated psychosis (DUP) were conducted to characterize the controllability progression pattern without treatment effects. Relative to HCs, patients exhibited reduced AC in multiple nodes, mainly distributed in default mode network (DMN), visual network (VN), and subcortical regions, and increased AC in somatomotor network. These networks also had impaired functional topology and increased temporal variability in dynamic functional connectivity analysis. Longer DUP was related to greater reductions of AC in VN and DMN. The current study highlighted potential structural substrates underlying altered functional dynamics in schizophrenia, providing a novel understanding of the relationship of anatomic and functional network alterations.

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Source
http://dx.doi.org/10.1093/cercor/bhac421DOI Listing

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