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Automatic labeling of facial zones for digital clinical application: An ensemble of semantic segmentation models.
Skin Res Technol
February 2024
AbbVie, Irvine, California, USA.
Introduction: The application of artificial intelligence to facial aesthetics has been limited by the inability to discern facial zones of interest, as defined by complex facial musculature and underlying structures. Although semantic segmentation models (SSMs) could potentially overcome this limitation, existing facial SSMs distinguish only three to nine facial zones of interest.
Methods: We developed a new supervised SSM, trained on 669 high-resolution clinical-grade facial images; a subset of these images was used in an iterative process between facial aesthetics experts and manual annotators that defined and labeled 33 facial zones of interest.
Outcomes of Surgical Treatment of Malar Mounds and Festoons.
Aesthetic Plast Surg
August 2023
Napa Solano Plastic Surgery, Napa, CA, USA.
Article Synopsis
- Malar mounds (congenital) and festoons (acquired) are persistent puffiness in the facial area, and this paper discusses a surgical technique to treat these issues, focusing on a study of 89 cases.
- The surgical correction involves a combination of procedures including a subciliary skin-muscle flap and midface lift, with the study analyzing outcomes over a follow-up period of at least six months.
- Results indicate that most patients had acquired festoons and, while some experienced persistent malar edema post-surgery, the condition improved with specific treatments, demonstrating the effectiveness of the surgical approach.
Specific-class Skin Side-effects of Drugs Might Compromise Blinding in Randomized Controlled Trials.
Acta Derm Venereol
February 2023
Department of Dermatology, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Henri Mondor, Paris, France; Universities of Tours et Nantes, INSERM 1246-SPHERE, Nantes, France.
Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review.
Antioxidants (Basel)
August 2021
School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria-Gazzi, 98125 Messina, Italy.
The current knowledge about the mechanisms of action of light-based treatments (chiefly photodynamic therapy and phototherapy) in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and exploit, to the fullest, these relatively safe and reproducible treatments, several studies have focused on miRNAs, small non-encoding RNAs (22-24 nucleotides), after light-based treatments. The current narrative review focused on 25 articles.
View Article and Find Full Text PDFNucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities.
Int J Mol Sci
June 2021
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Nucleotide excision repair (NER) is the most versatile DNA repair pathway, which can remove diverse bulky DNA lesions destabilizing a DNA duplex. NER defects cause several autosomal recessive genetic disorders. Xeroderma pigmentosum (XP) is one of the NER-associated syndromes characterized by low efficiency of the removal of bulky DNA adducts generated by ultraviolet radiation.
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