AI Article Synopsis
- Increased amounts of dermal mDCs (CD11c cells) were linked to higher itch intensity in prurigo nodularis (PN) skin lesions, as shown through immunofluorescence (IF) studies.
- These mDCs were found to express IL-31, a cytokine associated with itch, demonstrating a potential role in itch mechanisms.
- The study also highlighted that mDCs expressing IL-31 mRNA were more prevalent than CD68 macrophages and CD3 T cells in the PN skin lesions, suggesting their significant involvement in itch response.
Article Abstract
The number of dermal mDCs (CD11c cells) was increased with itch intensity ( = 0.886, = 0.003) using immunofluorescence (IF). On IF, CD11c mDCs expressed IL-31 in lesional PN skin. Fluorescence in situ hybridization combined with IF also confirmed IL-31 mRNA expression by mDCs in PN lesion. Higher population of colocalization of CD11c mDCs expressing IL-31 mRNA were more than CD68 macrophages and CD3 T cells in consecutive sections of PN skin lesion. HC, healthy control; PN, prurigo nodularis; SPN, PN with severe pruritus (itch NRS score ≥7 points); MPN, PN with mild pruritus (itch NRS score <3 points); NRS, Numeric Rating Scale; AD, atopic dermatitis; mDC, myeloid dendritic cell.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921813 | PMC |
| http://dx.doi.org/10.1002/mco2.204 | DOI Listing |
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