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Fluoride-Induced Autophagy and Apoptosis in the Mouse Ovary: Genomic Insights into IL-17 Signaling and Gut Microbiota Dysbiosis.
J Agric Food Chem
January 2025
Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China.
Chronic fluoride (F) exposure is linked to gonadotoxicity in females, yet the underlying molecular mechanisms remain unclear. This study investigated fluoride-induced reprotoxicity using advanced genomic profiling. RNA-seq analysis identified significant activation of autophagy, apoptosis, and IL-17 signaling pathways in fluoride-exposed female mice.
View Article and Find Full Text PDFLong-Term Effects on Gonadal Function After Treatment of Colorectal Cancer: A Systematic Review and Meta-Analysis.
Cancers (Basel)
November 2024
Division of Gynecological Endocrinology and Reproductive Medicine, University Women's Hospital, Inselspital Bern, University of Bern, 3010 Bern, Switzerland.
Background: The incidence of colorectal cancer (CRC) is increasing in the population under 50 years of age, with more than 10% of cases occurring in young adults. Fertility preservation counseling has therefore received increased attention in this younger patient population. The treatment of CRC is often based on multimodal therapies, including surgery, radiotherapy, chemotherapy, and, more recently, immunotherapy, which makes it difficult to estimate the expected effect of treatment on fertility.
View Article and Find Full Text PDFFolliculogenesis resumption after ovarian cortex transplantation: what is the earliest hormonal indicator?
Arch Gynecol Obstet
December 2024
Department of Assisted Reproductive Technologies and Fertility Preservation, Jeanne de Flandre Hospital, CHU Lille, 59000, Lille, France.
Introduction: Ovarian tissue cryopreservation (OTC) is recommended by scientific societies for women undergoing highly gonadotoxic cancer treatments. Following transplantation, the restoration of ovarian function is typically characterised by the resumption of spontaneous menstruation. Yet, a few studies have looked at the longitudinal hormonal variations following transplantation.
View Article and Find Full Text PDFEvidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model.
Front Endocrinol (Lausanne)
October 2024
Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Introduction: The mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclophosphamide and other cytotoxic drugs are currently understood through two main explanatory theories: apoptosis and over-activation. Discrepancies between the findings of different studies investigating these mechanisms do not allow to reach a firm conclusion. The heterogeneity of cell types in ovaries and their different degrees of sensitivity to damage, cell-cell interactions, periodical follicle profile differences, model age-dependent differences, and differences of exposure durations of tested drugs may partially explain the discrepancies among studies.
View Article and Find Full Text PDFFertility Preservation for Iatrogenic Infertility: Patient Barriers and Opportunities for the Reproductive Medicine Workforce.
Urol Pract
October 2024
Department of Urology, Houston Methodist Hospital, Houston, TX 77030.
Article Synopsis
- - Iatrogenic infertility can occur from necessary medical treatments like chemotherapy, radiation, certain surgeries, and hormone therapy, making fertility preservation (FP) crucial for patients hoping to conceive in the future.
- - Despite increasing awareness of FP, patients face significant barriers, primarily high costs, limited access to specialists, lack of education among both providers and patients, and stigma surrounding reproductive health.
- - Improving insurance coverage for FP, enhancing educational efforts, and leveraging new healthcare technologies can help mitigate these barriers, ultimately benefiting patients and their quality of life, with urologists playing a key role in advocacy and care.
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