AI Article Synopsis
- Renal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury, and its mechanisms are not fully understood, particularly the role of OGG1 (8-oxoguanine DNA glycosylase).
- This study identifies OGG1 as a crucial factor in promoting cell death and tissue damage during renal IRI, as it negatively affects mitophagy by inhibiting the PINK1/Parkin pathway.
- Targeting OGG1 through knockout or drug inhibition mitigates renal IRI by restoring mitophagy, highlighting the potential therapeutic role of enhancing this process in kidney injury recovery.
Article Abstract
Renal ischemia-reperfusion injury (IRI) is mainly responsible for acute kidney injury for which there is no effective therapy. Accumulating evidence has indicated the important role of mitophagy in mitochondrial homeostasis under stress. OGG1 (8-oxoguanine DNA glycosylase) is known for functions in excision repair of nuclear and mitochondrial DNA. However, the role of OGG1 in renal IRI remains unclear. Herein, we identified OGG1, induced during IRI, as a key factor mediating hypoxia-reoxygenation-induced apoptosis in vitro and renal tissue damage in a renal IRI model. We demonstrated that OGG1 expression during IRI negatively regulates mitophagy by suppressing the PINK1/Parkin pathway, thereby aggravating renal ischemic injury. OGG1 knockout and pharmacological inhibition attenuated renal IRI, in part by activating mitophagy. Our results elucidated the damaging role of OGG1 activation in renal IRI, which is associated with the regulatory role of the PINK1/Parkin pathway in mitophagy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392062 | PMC |
| http://dx.doi.org/10.1111/cpr.13418 | DOI Listing |
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