AI Article Synopsis
- The study investigates the cytotoxic effects of ethanol extract from the aerial parts of a plant, traditionally used in Brazil for treating diseases, on gastric adenocarcinoma cells (AGS), as well as its chemical composition.
- Hexane and aqueous fractions of the extract displayed higher cytotoxicity against AGS cells, indicating potential effectiveness in cancer treatment.
- Key compounds identified include triterpenes like euphol and friedelin in the hexane fraction, and ellagic acid as the main phenolic compound in the aqueous extract, which are believed to contribute to the extract's antiproliferative effects against cancer cells.
Article Abstract
Ethanol extract from the aerial parts of L. as well as the latex of the plant suspended in water are used by the Brazilian population for the treatment of various diseases, including cancer. The purposes of this study were to determine if the ethanol extract is effective as cytotoxic agent against gastric adenocarcinoma cells (AGS) and its chemical composition by GC-MS, ESI-(-)-FT-ICR MS and (-)-ESI-LTQ-MS/MS. The results were compared with that of latex previously described by us. Hexane and aqueous fractions showed higher cytotoxicity on AGS cells. Nine triterpene compounds were detected by GC-MS in hexane fraction, including euphol and friedelin, while ellagic acid was identified as main phenolic compound in aqueous extract. Therefore, the greater cytotoxic activity of the ethanol extract of the aerial parts of for gastric cancer, when compared to latex, seems to originate from the antiproliferative effects of ellagic acid and triterpenes.
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| http://dx.doi.org/10.1080/14786419.2023.2179623 | DOI Listing |
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