AI Article Synopsis
- Hormone receptor-positive breast cancer is the most common type of breast cancer, and the protein phosphatase PP1A gene is identified as an oncogene, though its role in this subtype is not well understood.
- Research showed that PP1A is more expressed in hormone receptor-positive breast cancer compared to normal breast tissue, and it promotes cancer cell proliferation both in lab tests and animal models.
- The study uncovered a pathway involving LINC02754, E2F1, PP1A, and YAP1 that drives cancer progression by activating YAP1 and increasing the expression of the oncogene CTGF.
Article Abstract
Hormone receptor-positive breast cancer is the most common subtype of breast cancer. The protein phosphatase PP1A gene is described as an oncogene in several tumor types; however, the biological function of PP1A in hormone receptor-positive breast cancer remains unclear. The Cancer Genome Atlas data indicates PP1A expression is upregulated in hormone receptor-positive breast cancer tissues than in normal breast tissues. We explored the biological function of PP1A in hormone receptor-positive breast cancer using MTT assays, colony formation assays, and a xenograft mouse model. The results indicated that PP1A promoted hormone receptor-positive breast cancer proliferation, both in vitro and in vivo. Mechanistically, LINC02754 recruited the binding of the transcription factor E2F1 to the PP1A promotor, thereby increasing PP1A expression. The PP1A then interacted with and dephosphorylated YAP1, resulting in YAP1 activation. The dephosphorylated YAP1 moved to the nucleus and increased the expression of the downstream oncogene CTGF, promoting hormone receptor-positive breast cancer progression. Our findings reveal the function of the LINC02754/E2F1/PP1A/YAP1 axis in hormone receptor-positive breast cancer and provide new insight into hormone receptor-positive breast cancer progression.
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| http://dx.doi.org/10.1016/j.biocel.2023.106389 | DOI Listing |
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