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Article Abstract
Hyperprogression is a paradoxical cancer acceleration observed in a minority of patients upon immunotherapy. In this issue of Cancer Cell, Li et al demonstrate that hyperprogressive tumors upregulate the Wnt/β-catenin pathway. This activation was subsequent to an oncogenic FGF2-mediated autocrine loop generated by the IFNγ released by CD8 T cells upon PD-1/PD-L1 blockade.
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| http://dx.doi.org/10.1016/j.ccell.2023.01.006 | DOI Listing |
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