Neutrophils constitute a considerable proportion of all leukocytes found in tumors and are essential for promoting tumor growth. In this issue, Linde et al. demonstrate that an antibody cocktail therapy consisting of tumor necrosis factor (TNF), anti-CD40 monoclonal antibody, and tumor-binding antibody can boost the anti-tumor activity of neutrophils.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccell.2023.01.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Use of Different Synbiotic Strategies to Improve Gut Health in Dogs.
Animals (Basel)
November 2024
Nutrition and Welfare Service, Department of Animal and Food Science, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
This study evaluated the effects of two synbiotic strategies on the intestinal microbiota and immune response in Beagle dogs. Twelve dogs were subjected to a crossover design with three diets: a control diet (CON), a diet supplemented with fiber and DSM 15544 (SYN), and the SYN diet with added porcine plasma (SYN+). Over three periods of seven weeks, fecal samples were analyzed for digestibility, short-chain fatty acids (SCFA), fecal markers, and microbiome composition, while blood samples were assessed for biochemical parameters, leucocytic counts including CD4/CD8 lymphocyte populations, and phagocytic activity.
View Article and Find Full Text PDFComparison of Hematological Parameters and the Associated Factors Among Women with and without Breast Cancer: A Case-Control Study.
Breast Cancer (Dove Med Press)
December 2024
Department of Medical Laboratories, Faculty of Medical Sciences, International Malaysian University, Ibb City, Yemen.
Background: Breast cancer (BC) is the most popular and dangerous cancer, with a high mortality rate. Hematological parameters are often used in routine diagnosis of numerous disorders. Therefore, the study aimed to evaluate hematological parameters amongst women with and without BC.
View Article and Find Full Text PDFComparison of Adverse Effect Profiles of Nafcillin and Oxacillin in Pediatric Patients.
J Pediatr Pharmacol Ther
December 2024
Department of Practice, Sciences, and Health Outcomes Research (JAM, KAP), University of Maryland School of Pharmacy, Baltimore, MD.
Objective: Data comparing the safety profiles of nafcillin and oxacillin are limited in the pediatric patient setting. This study was conducted to compare adverse effect profiles of nafcillin and oxacillin.
Methods: This was a single center retrospective study including patients admitted to a children's hospital who received either nafcillin or oxacillin.
Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment.
Genome Biol
December 2024
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Article Synopsis
- Immunotherapy has enhanced survival rates for patients with advanced clear cell renal cell carcinoma (ccRCC), but many patients still develop resistance to treatment.
- A study examined tumor samples from patients with both treatment-naïve and treatment-exposed ccRCC, revealing that tumors exposed to immunotherapy contained more immune cells (like CD8+ T cells and neutrophils) and showed significant changes in cellular markers.
- Key findings included increased expression of COL4A1 and ITGAV in the stroma of treated tumors, suggesting a need for further investigation into how these changes impact the tumor immune environment and potential new therapies.
Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients.
Future Sci OA
December 2024
Facultad de Ciencias de la Salud, Universidad Espíritu Santo, Samborondón, Ecuador.
Aims/background: We looked at novel hematological composites like the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, red cell distribution width-to-lymphocyte ratio, red cell distribution width-to-platelet ratio, leukocyte-to-C reactive protein ratio, and lymphocyte-to-C reactive protein ratio as explanatory variables for COVID-19 patients´ hospital length of stay (LoS).
Methods: The association of hematological indices with LoS was analyzed on 2930 COVID-19 patients using the univariate and multivariable Cox proportional hazards regression models with enter method. The Kaplan-Meier survival estimates were applied to LoS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!