Oxidatively modified plasma lipoproteins play an important role in the molecular mechanisms of vascular wall damage in atherosclerosis and diabetes mellitus. It was found that the oxidizability of low-density lipoproteins (LDLs) is more than one order of magnitude higher than that of high-density lipoproteins (HDLs). It was shown that acylhydroperoxy derivatives of phospholipids of oxidized biomembranes are predominantly captured by LDL particles, but not by HDLs, which refutes the hypothesis about the involvement of HDLs in the reverse transport of lipohydroperoxides (LOOH). The results suggest the possibility of different mechanisms of LOOH accumulation in LDLs: due to the increased oxidizability of LDLs and due to the effective transmembrane transport of LOOH by LDL particles.
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