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Quantitative photoacoustic imaging using known chromophores as fluence marker.
Photoacoustics
February 2025
Erasmus MC, Cardiovascular Institute, Department of Cardiology, Biomedical Engineering, Rotterdam, The Netherlands.
Photoacoustic imaging offers optical contrast images of human tissue at acoustic resolution, making it valuable for diverse clinical applications. However, quantifying tissue composition via optical contrast remains challenging due to the unknown light fluence within the tissue. Here, we propose a method that leverages known chromophores (, arterial blood) to improve the accuracy of quantitative photoacoustic imaging.
View Article and Find Full Text PDFClassification of Scanning Errors of Digital Scans Recorded by Using Intraoral Scanners.
J Esthet Restor Dent
January 2025
Department of Restorative Dentistry, University of Washington; Founder and Director, Kois Center, Seattle, Wash; and Private Practice, Seattle, WA, USA.
Objectives: The different scanning errors that can be caused by the operator handling an intraoral scanner (IOS) or the intraoral conditions of the patient being scanned have not been described. The purpose of this review was to describe and classify the scanning errors that can be identified in digital scans recorded by using IOSs.
Overview: The identification of scanning errors in an intraoral scan and understanding the cause of these scanning errors are fundamental procedures for successfully handling an IOS and integrating these digital data acquisition technologies in dental practices.
Skeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes.
Eur Heart J
January 2025
Cardiovascular Imaging Program, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
Background And Aims: Skeletal muscle (SM) fat infiltration, or intermuscular adipose tissue (IMAT), reflects muscle quality and is associated with inflammation, a key determinant in cardiometabolic disease. Coronary flow reserve (CFR), a marker of coronary microvascular dysfunction (CMD), is independently associated with body mass index (BMI), inflammation and risk of heart failure, myocardial infarction, and death. The relationship between SM quality, CMD, and cardiovascular outcomes is not known.
View Article and Find Full Text PDFFORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models.
Commun Med (Lond)
January 2025
Dyne Therapeutics Inc, Waltham, MA, USA.
Background: We developed the FORCE platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an antigen-binding fragment, highly specific for the human transferrin receptor 1 (TfR1), conjugated to an oligonucleotide via a cleavable valine-citrulline linker. Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression.
View Article and Find Full Text PDFCorrection to: The N400 component reflecting semantic and repetition priming of visual scenes is suppressed during the attentional blink.
Atten Percept Psychophys
January 2025
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE, 19716-2577, USA.
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