AI Article Synopsis
- Genital herpes is a lifelong sexually transmitted infection caused by HSV-1 and HSV-2, with no available cure; antiviral medications can help manage symptoms.
- The US Preventive Services Task Force (USPSTF) evaluated the evidence regarding routine screening for HSV-2 in asymptomatic individuals, reaffirming their recommendation from 2016.
- They concluded that the potential harms of routine screening in asymptomatic adolescents, adults, and pregnant persons exceed any benefits, leading to a recommendation against such screening.
Article Abstract
Importance: Genital herpes is a common sexually transmitted infection caused by 2 related viruses, herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2). Infection is lifelong; currently, there is no cure for HSV infection. Antiviral medications may provide clinical benefits to symptomatic persons. Transmission of HSV from a pregnant person to their infant can occur, most commonly during delivery; when genital lesions or prodromal symptoms are present, cesarean delivery can reduce the risk of transmission. Neonatal herpes infection is uncommon yet can result in substantial morbidity and mortality.
Objective: To reaffirm its 2016 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a reaffirmation evidence update on targeted key questions to systematically evaluate the evidence on accuracy, benefits, and harms of routine serologic screening for HSV-2 infection in asymptomatic adolescents, adults, and pregnant persons.
Population: Adolescents and adults, including pregnant persons, without known history, signs, or symptoms of genital HSV infection.
Evidence Assessment: The USPSTF concludes with moderate certainty that the harms outweigh the benefits for population-based screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons.
Recommendation: The USPSTF recommends against routine serologic screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons. (D recommendation).
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| http://dx.doi.org/10.1001/jama.2023.0057 | DOI Listing |
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