Anisotropic H STD-NMR Spectroscopy: Exploration of Enantiomer-Polypeptide Interactions in Chiral Oriented Environments.

Chemphyschem

Université Paris-Saclay, UFR d'Orsay, RMN en Milieu Orienté, ICMMO, UMR CNRS 8182, Bât. 410, 15, rue du Doyen Georges Poitou, 91405, Orsay cedex, France.

Published: February 2023

The front cover artwork is provided by Dr. Philippe Lesot's group (NMR in Oriented Media, ICMMO, UMR CNRS 8182) at Université Paris-Saclay, France. The image shows four pieces of a puzzle: the magnet of an NMR spectrometer, the principle of the H STD-NMR experiment and the 3D helical structure of the poly-γ-benzyl-L-glutamate polymer leading to a chiral liquid-crystalline phase that discriminates the enantiomers of a model chiral solute (1-phenethyl alcohol). Putting these pieces of the puzzle together allows us to identify the hydrogen sites of each enantiomer interacting with the polypeptide side chain. These new outcomes are a further step towards a global understanding of the chiral recognition that occurs in such media. Read the full text of the Research Article at 10.1002/cphc.202200508.

Download full-text PDF

Source
http://dx.doi.org/10.1002/cphc.202300040DOI Listing

Publication Analysis

Top Keywords

pieces puzzle
8
anisotropic std-nmr
4
std-nmr spectroscopy
4
spectroscopy exploration
4
exploration enantiomer-polypeptide
4
enantiomer-polypeptide interactions
4
chiral
4
interactions chiral
4
chiral oriented
4
oriented environments
4

Similar Publications

Background: Surgical treatment of comminuted and multiple facial fractures is challenging, as identifying the bone anatomy and restoring the alignment are complicated. To overcome the difficulties, 3D-printed "jigsaw puzzle" has been innovated to improve the surgical outcome. This study aimed to demonstrate the feasibility of 3D-printed model in facial fracture restoration procedures.

View Article and Find Full Text PDF

The pathogenesis of atopic dermatitis (AD) points to skin barrier dysfunction as a critical piece of the puzzle. Deficiencies in fatty acids and ceramides-key elements of the skin barrier-have been linked to AD. Fatty acids can be separated into omega-3 and omega-6, which can be found in a variety of foods such as fish, nuts, seeds, and even plants.

View Article and Find Full Text PDF

Missing pieces in the puzzle of ecology of microbial arsenate reduction.

J Hazard Mater

December 2024

Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Academy of Sciences, Guangzhou 510650, China.

Arsenic pollution and its associated health risks have raised widespread concern. Under anaerobic conditions, arsenic mobility and toxicity increase when arsenate [As(V)] is reduced to arsenite [As(III)] by microbes through the cytoplasmic and dissimilatory pathways. However, the relative importance of these two pathways in the environment remains unclear, restricting our ability to effectively predict and regulate the environmental behavior of arsenic.

View Article and Find Full Text PDF

Evidence suggests that a healthy gut microbiome is essential for metabolizing dietary phytochemicals. However, the microbiome's role in metabolite production and the influence of gut dysbiosis on this process remain unclear. Further, studies on the relationship among gut microbes, metabolites, and biological activities of phytochemicals are limited.

View Article and Find Full Text PDF

Firearm-related scenarios can be highly complex, involving multiple shooters, firearms, types of ammunition, victims, and various impact zones. Obtaining the maximum amount of information to connect each piece of the puzzle is crucial for resolving these cases. Currently, new tools are being developed in the forensic field that facilitate both fieldwork and laboratory analysis, enabling the estimation of trajectories, identification of shooters, and more.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!