AI Article Synopsis
- - Two new azaphilones, named penimultiones A and B, were discovered along with seven existing compounds from the fungus Penicillium multicolor LZUC-S2.
- - The structures of these new compounds were determined using advanced spectroscopic techniques and chemical reactions.
- - When tested for antibacterial effects against five different bacteria, three compounds demonstrated strong activity, with minimum inhibitory concentrations (MIC) between 12.5 and 50.0 μg/mL.
Article Abstract
Two new azaphilones, penimultiones A and B, together with seven known analogs were isolated from the culture of Penicillium multicolor LZUC-S2. Their structures were elucidated by detailed spectroscopic data analysis and chemical transformation. Penimultiones A and B belong to a rare class of azaphilones possessing a 1,3-dioxolane moiety. In addition, all compounds were evaluated for their antibacterial activity against five clinically bacterial strains in vitro, and three compounds showed potent antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 12.5 to 50.0 μg/mL.
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| http://dx.doi.org/10.1002/cbdv.202201180 | DOI Listing |
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