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Alcohol drinking leads to sex-dependent differentiation of T cells.
Eur J Trauma Emerg Surg
January 2025
Department of Trauma Surgery and Orthopedics, Goethe University, University Hospital, Frankfurt, Germany.
Objective: Global per capita alcohol consumption is increasing, posing significant socioeconomic and medical challenges also due to alcohol-related traumatic injuries but also its biological effects. Trauma as a leading cause of death in young adults, is often associated with an increased risk of complications, such as sepsis and multiple organ failure, due to immunological imbalances. Regulatory T cells play a crucial role in maintaining immune homeostasis by regulating the inflammatory response.
View Article and Find Full Text PDFQuality of orthodontic care in an academic setting in the Middle East.
Sci Rep
January 2025
Department of Orthodontics, Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Assessment of the quality of orthodontic care in a UAE-based orthodontic postgraduate training institution was conducted using multiple indices, including the Peer Assessment Rating (PAR), American Board of Orthodontics Objective Grading System (ABO-OGS), and Index of Complexity Outcome and Need (ICON). Retrospective evaluation of pre- and post-treatment records of patients (n = 201) treated with fixed orthodontic appliances was performed by two examiners Statistical analysis assessed the influence of gender, type of malocclusion, need for extraction, missed appointments and number of treating residents on treatment duration. The average numerical reduction of the PAR and ICON scores at the start and end of the treatment were 17.
View Article and Find Full Text PDFHER2 expression and pathway status in male breast cancer patients: results of an integrated analysis among 6,150 patients.
Sci Rep
January 2025
Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710014, Shaanxi Province, China.
The role of human epidermal growth factor 2 (HER2) in male breast cancer (MBC) is poorly defined. A comprehensive description of HER2 status was conducted. A total of 6,015 MBC patients from 45 studies and 135 MBC patients with sequencing data were identified.
View Article and Find Full Text PDFSince the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the need for an effective vaccine has appeared crucial for stimulating immune system responses to produce humoral/cellular immunity and activate immunological memory. It has been demonstrated that SARS-CoV-2 variants escape neutralizing immunity elicited by previous infection and/or vaccination, leading to new infection waves and cases of reinfection. The study aims to gain into cases of reinfections, particularly infections and/or vaccination-induced protection.
View Article and Find Full Text PDFIntervention Stage Completion and Behavioral Health Outcomes: An Integrated Behavioral Health and Primary Care Randomized Pragmatic Trial.
Ann Fam Med
January 2025
Department of Family Medicine, University of Colorado, Denver, Colorado.
Purpose: We performed a pragmatic, cluster randomized controlled trial of a comprehensive practice-level, multistage practice transformation intervention aiming to increase behavioral health integration in primary care practices and improve patient outcomes. We examined associations between completion of intervention stages and patient outcomes across a heterogeneous national sample of primary care practices.
Methods: Forty-two primary care practices across the United States with colocated behavioral health and 2,945 patients with multiple chronic medical and behavioral health conditions completed surveys at baseline, midpoint, and 2-year follow-up.
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