Oxidative condensation of three p-phenylenediamines with 3-hydroxy-2-methyl-N-(phenylamino)benzene gives new coloured aposafranones. 2-Methylresorcinol is easy to convert into the asymmetric building block 3-hydroxy-2-methyl-N-(phenylamino)benzene with aniline. The aposafranones are sterically crowded because of the 1-methyl and N-phenyl groups. The UV/Vis absorption maxima are in the range 530-545 nm.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925832 | PMC |
| http://dx.doi.org/10.1002/open.202300007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Divergent Synthesis of Axially Chiral 2-Pyranones and Fused 2-Pyridones via -Heterocyclic Carbene-Catalyzed Atroposelective [3 + 3] Annulation.
J Org Chem
January 2025
School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.
An -heterocyclic carbene-catalyzed atroposelective [3 + 3] annulation of alkynyl acylazoliums with benzothiazole derivatives has been developed for the divergent synthesis of axially chiral triaryl 2-pyranones and fused 2-pyridones. The regioselectivity of this protocol depends on the structure of benzothiazoles with three different nucleophilic centers. The obtained axially chiral frameworks represent a new class of arylheterocycle atropisomers, which may be potentially useful in medicinal chemistry.
View Article and Find Full Text PDFA Stable Open-Shelled Au26 Nanocluster with Remarkable Performance in Selective Oxidation of Benzyl Alcohol.
Angew Chem Int Ed Engl
January 2025
Tsinghua University, Chemistry Department, 1 Tsinghua Yuan, Haidian District, 100084, Beijing, CHINA.
Open metal sites are crucial in catalysis. We have used a "loose coordination strategy" (LCS) to preorganize open metal sites in gold cluster catalysts. A gold nanocluster with composition of [Au26(3,4-Me2-Ph-form)9(iPr2-imy)3(Me2S)](BF4)2(iPr2-imy = 1,3-Diisopropylimidazolium tetrafluoroborate, 3,4-Me2-Ph-form = N,N'-Di(3,4-dimethyl-phenyl)formamidine) (Au26) has been obtained by one pot synthesis, i.
View Article and Find Full Text PDFRadical -Adenosylmethionine Sulfurtransferase MybB Catalyzed Formation of the 4-Thiazolidinone Core in Mycobacidin Represents an Intersection between Primary and Secondary Metabolism.
J Am Chem Soc
January 2025
Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Mycobacidin is an antitubercular antibiotic structurally composed of a sulfur-containing 4-thiazolidinone ring, yet its biosynthesis including the mechanism of sulfur incorporation has remained an open question since its discovery in 1952. In this study, the mycobacidin biosynthetic gene cluster is identified from soil-dwelling , and the corresponding biosynthetic pathway starting with 7-oxoheptanoate is characterized. The radical SAM enzyme MybB catalyzes two sulfur insertion reactions, thereby bridging C and C to complete the 4-thiazolidinone heterocycle as the final step in mycobacidin maturation.
View Article and Find Full Text PDFInfluence of Drying Methods on the Morphological Features, Microstructural Properties, and Antioxidant Performance of : A Metabolomic Analysis.
J Fungi (Basel)
January 2025
State Key Laboratory of Plateau Ecology and Agriculture, Qinghai Academy of Animal and Veterinary Science, Xining 810016, China.
() has garnered increasing attention as an ingredient in both the pharmaceutical and food industries. Depending on the drying method, the accumulation of metabolites can greatly affect the quality. This research employed an untargeted metabolomics (LC-MS/MS) strategy to elucidate the similarities and differences in the morphological characteristics, microstructure, antioxidant capacity, and metabolic profiles of subjected to three distinct drying methods: natural air-drying (YG), oven-drying (HG), and vacuum freeze-drying (DG).
View Article and Find Full Text PDFA Comprehensive Review: Synthesis and Pharmacological Activities of 1,3,4-Oxadiazole Hybrid Scaffolds.
Med Chem
January 2025
Department of Pharmacy, Division of Research and Innovation, Chandigarh Pharmacy College, Chandigarh Group of Colleges, Jhanjeri, Mohali, Punjab 140307, India.
Introduction: Heterocyclic derivatives, particularly those containing heteroatoms such as oxygen and nitrogen, represent a significant portion of currently marketed drugs. Among these, the aromatic heterocycle 1,3,4-oxadiazole, characterized by an N=C=O-linkage, stands out due to its remarkable biological activities. These activities include anti-inflammatory, anti-cancer, antioxidant, anti-tubercular, antiviral, anti-diabetic, and antibacterial effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!