Background: gene mutations related to hearing loss patients can obtain good hearing and speech rehabilitation effects after cochlear implantation (CI).
Objective: To explore the long-term rehabilitative outcomes of CI in patients with different mutation groups.
Material And Methods: Clinical data of 71 patients with gene mutations who received CI in the Second Hospital of Lanzhou University from 2012 to 2015 were retrospectively reviewed. According to the genetic test results, use One-way ANOVA analysis to compare the differences in auditory results, categories of auditory performance (CAP) and speech intelligibility rating (SIR) index questionnaire scores and speech recognition rates among different groups in 4-5 years after CI.
Result: Compared with other genotypes of , the patients with homozygous mutation of c.919-2A > G in had better hearing aid threshold at 500 Hz and better recognition rates of Yangyang words than other monoallelic mutation groups after CI ( < .05).
Conclusions And Significance: The most common hot spot mutation of gene is c.919-2A > G. The patients with homozygous mutation of c.919-2A > G in gene had partly better hearing and speech rehabilitation than other monoallelic mutation groups after CI.
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| http://dx.doi.org/10.1080/00016489.2023.2174592 | DOI Listing |
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