Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to strongly reduce aspartimide formation compared to piperidine (PPR) in high-temperature (60 °C) solid-phase peptide synthesis (SPPS). In contrast to PPR, DPA is readily available, inexpensive, low toxicity, and nonstench. DPA also provides good yields in SPPS of non-aspartimide-prone peptides and peptide dendrimers.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910063 | PMC |
| http://dx.doi.org/10.1021/acsomega.2c07861 | DOI Listing |
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